Pecan nut oil to lower inflammation in adults with overweight
Official title: Anti-Inflammatory Effects of Pecan Nut Oil Supplementation in Adults With Overweight: A Non-Randomized Controlled Parallel-Group Clinical Trial
Run by Universidad Autonoma de Nuevo Leon · NCT07497555 · Data updated 2026-11-12
This will see if taking 30 g/day of cold-pressed pecan nut oil for 8 weeks can lower blood inflammation markers and improve blood sugar and cholesterol in adults with overweight (BMI 25–30).
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Universidad Autonoma de Nuevo Leon Academic / other |
| Locations | 1 site (Monterrey, Nuevo León) |
| Status | Recruiting |
| Started | October 15, 2025 |
| Main results expected | July 30, 2026 |
| Study ends | July 30, 2026 |
| Registry record updated | March 27, 2026 |
| Trial ID | NCT07497555 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with BMI 25 to <30 kg/m² who are otherwise healthy, not taking anti-inflammatory or lipid-lowering medications, non-smokers, not pregnant or lactating, and able to attend two clinic visits and keep stable diet and activity.
✕Probably not a fit
People with obesity (BMI ≥30), diagnosed diabetes, cardiovascular, liver or kidney disease, smokers, those on anti-inflammatory or lipid-lowering drugs, pregnant or lactating individuals, and anyone with nut allergy are excluded and would not be expected to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, parallel-group trial compares daily supplementation with 30 g of cold-pressed pecan nut oil to a no-intervention control over 8 weeks in adults with overweight. Participants attend two in-person visits (baseline and Day 60) for blood sampling and anthropometric measurements, and provide dietary information while maintaining usual diet and activity. Primary outcomes include inflammatory biomarkers (CRP, IL-6, TNF-α) and secondary outcomes include fasting glucose and lipid profile. Individuals with chronic diseases, use of anti-inflammatory or lipid-lowering drugs, smoking, pregnancy, or nut allergy are excluded to reduce confounding.
Why it matters
Potential benefit: If effective, daily pecan nut oil could provide a simple dietary supplement to reduce chronic low-grade inflammation and modestly improve metabolic markers in adults with overweight.
How similar studies have gone: Research on nut-rich diets and some nut oils has shown modest anti-inflammatory and metabolic benefits, but cold-pressed pecan oil has been relatively untested in randomized trials.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 65 years * Body mass index (BMI) ≥25 and \<30 kg/m² (overweight) * Willingness to participate and provide written informed consent * Ability to comply with study procedures and attend scheduled visits * Stable dietary habits and physical activity levels during the study period Exclusion Criteria: * Diagnosis of chronic diseases such as diabetes mellitus, cardiovascular disease, liver disease, renal disease, or autoimmune disorders * Use of anti-inflammatory medications, lipid-lowering drugs, or dietary supplements within the last 3 months * Smoking or excessive alcohol consumption * Pregnancy or lactation * Known allergy or intolerance to nuts or nut-derived products * Participation in another clinical trial within the last 3 months * Any condition that, in the investigator's opinion, may interfere with study participation or outcomes
Where it's running
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Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León
Monterrey, Nuevo León, Mexico Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.