Patient and caregiver perspectives on bladder instillations for urinary symptoms
Official title: Intravesical Gentamicin Coupled With Lactobacillus Rhamnosus for Urinary Health- Early Career
Run by Medstar Health Research Institute · NCT07390591 · Data updated 2026-11-12
This project talks with adults who have neurogenic bladder and their caregivers to see what they prefer and experience with bladder instillations of Lactobacillus, gentamicin, or both.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Medstar Health Research Institute Academic / other |
| Locations | 1 site (Washington D.C., District of Columbia) |
| Status | Recruiting |
| Started | June 19, 2025 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | February 5, 2026 |
| Trial ID | NCT07390591 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (18+) with NLUTD who have used chronic catheters for at least six months and have personal experience receiving intravesical Lactobacillus, gentamicin, or both, as well as caregivers who have facilitated those instillations.
✕Probably not a fit
People without prior experience with these intravesical treatments, those not community-dwelling, or those unable to provide informed consent due to psychiatric conditions are unlikely to gain direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational qualitative project uses one-hour semi-structured interviews with adults with neurogenic lower urinary tract dysfunction (NLUTD) and their caregivers to explore experiences with intravesical Lactobacillus-only, gentamicin-only, and combined instillations. Participants may be invited to brief follow-up discussions within 12 months, with total participation time capped at 2.5 hours. Interviews are audio-recorded, transcribed, and analyzed using a secure cloud-based qualitative analysis platform, and recruitment will continue until thematic saturation is reached. Responses from four groups—Lactobacillus-only users, gentamicin-only users, combined users, and caregivers—will be compared to identify preferences, perceived benefits, and barriers.
Why it matters
Potential benefit: If successful, the findings could help align instillation approaches with patient preferences, improving comfort, adherence, and potentially reducing infection risk.
How similar studies have gone: Some clinical studies have shown intravesical antibiotics can reduce urinary infections, but qualitative research on patient and caregiver views specifically about Lactobacillus and gentamicin instillations is limited and relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Criteria for patients: * Age 18+ * Diagnosis of NLUTD * Chronic catheter usage (minimum 6 months), either intermittent catheterization or indwelling catheter * Community-dwelling * Experience using intravesical Lactobacillus, gentamicin, or combination of the two Criteria for caregivers: * Age 18+ * Care for patient with diagnosis of NLUTD * Care for patient who has used catheters chronically (minimum 6 months) * Experience facilitating patients' use of intravesical Lactobacillus, gentamicin, or combination of the two Exclusion Criteria: * Psychiatric or psychologic conditions impacting ability to consent
Where it's running
-
Medstar National Rehabilitation Hospital
Washington D.C., District of Columbia, United States Recruiting
Study contacts
- Principal investigator: Ana Valeria Aguirre Guemez, MD — MedStar National Rehabilitation Hospital
- Study coordinator: Christopher Riegner, MPH
- Email: Christopher.R.Riegner@medstar.net
- Phone: 202-892-5857
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Improving pelvic rehabilitation after spinal cord injury with epidural stimulation
This study is testing if using a special device to stimulate the spinal cord can help people with spinal cord injuries improve their bladder and bowel function through pelvic rehabilitation.
-
Comparing Lactobacillus Rhamnosus GG with saline bladder wash for preventing UTIs in spinal cord injury patients
This study is testing if a special probiotic combined with a saline bladder wash can help prevent urinary tract infections in people with spinal cord injuries.
-
Transcutaneous spinal cord stimulation with 4-aminopyridine and intensive rehab for chronic spinal cord injury
This pilot study tests whether combining noninvasive spinal stimulation, dalfampridine, and rigorous rehab is safe and feasible for adults with chronic spinal cord injury and whether it can help improve movement and walking.
-
NG004 for incomplete cervical spinal cord injury
This trial tests NG004 versus placebo to see if it is safe and helps motor function and daily life in adults with acute incomplete cervical spinal cord injury.
-
Robot-assisted training for arm and leg movement after stroke or injury
This study tests whether adding ZEPU-AI robotic training to usual therapy is safe and helps adults with arm or leg movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions.
-
Investigational Intermittent Catheter: First Look at Safety and Usability
This study tests a new intermittent catheter in adult men who already self-catheterize to see if it is safe and easy to use compared with their current catheter.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.