Partial enteral nutrition with a dairy-free diet for eosinophilic esophagitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study will offer pediatric and young adult patients (ages 1–21) a dietary regimen combining partial enteral nutrition (PEN) with elimination of dairy and compare findings before and three months after the intervention. Investigators will measure clinical and endoscopic remission, adherence, nutritional and anthropometric outcomes, and collect samples to profile immune markers, gut microbiota, and environmental contaminants. The protocol includes baseline evaluation and an endoscopic assessment at three months to determine tissue-level response. The study is sponsored by an industry partner (Kate Farms Inc.) in collaboration with Seattle Children's Hospital and is conducted at that single pediatric center.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pediatric patients 1 year to 21 of age presenting with chronic symptoms of dysphagia, odynophagia, vomiting or heartburn, chronic abdominal pain, weight loss, picky eating, to outpatient gastroenterology clinic and are planning to undergo EGD for evaluation.

Exclusion Criteria:

* Non-English-Speaking Subjects, adults unable to consent, wards of the state, pregnant women, and prisoners will be excluded from the study.
* Patients with autoimmune conditions such as inflammatory bowel disease. Patients with prior esophageal or intestinal surgeries.
* Patients with history of eating disorders or ARFID.
* Patients with fistulizing or fibrotic disease on baseline EGD.
* Patients who have received proton pump inhibitory therapy in the past month.

Where it's running

• Seattle Children's Hospital
  Seattle, Washington, United States Recruiting

Study contacts

• Principal investigator: Michael Pickens, DO — Seattle Children's Hospital
• Study coordinator: Danny Gagucas
• Email: Danny.Gagucas@seattlechildrens.org
• Phone: 206-987-1062

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.