Paragastric block to reduce pain and nausea after sleeve gastrectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective, randomized, double-blind controlled trial will enroll 180 adults undergoing elective laparoscopic sleeve gastrectomy and randomize them 1:1 to receive either a paragastric block with 20 mL 0.5% bupivacaine or a sham block with 20 mL saline injected at six predefined intraoperative sites. Pain will be measured using visual analog scales for early postoperative visceral pain, and PONV and analgesic consumption will be recorded in the immediate postoperative period. The injections target autonomic neural plexuses around the stomach, including branches of the celiac ganglia and vagal pathways, to address visceral pain that often persists despite somatic-focused multimodal analgesia. Outcomes will compare pain scores, incidence of PONV, and opioid requirements between groups under a double-blind protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Patients aged between 18 and 65 years.
* Candidates scheduled for elective LSG.
* American Society of Anesthesiologists (ASA) physical status classification I-III.
* Ability to provide written informed consent and willingness to comply with study procedures.

Exclusion Criteria

* History of prior upper abdominal surgery.
* Known psychiatric or neurological disorders that could interfere with pain assessment or postoperative care.
* History of opioid dependency or chronic opioid use.
* Allergy or hypersensitivity to local anesthetics or any of the medications used in the study protocol (e.g., paracetamol, dexketoprofen, ondansetron, tramadol, metoclopramide).
* Severe hepatic, renal, or cardiac dysfunction (e.g., cirrhosis, end-stage renal disease, heart failure).
* Pregnancy or breastfeeding.
* Concomitant surgery (e.g., cholecystectomy, hiatal hernia repair, or abdominal wall repair).
* Known bleeding disorders or coagulopathy (e.g., INR \>1.5, platelet count \<50,000/mm³, or ongoing anticoagulant therapy)

Where it's running

• Istanbul Gedik University
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Abdullah Sisik, MD, Professor of General Surgery
• Email: abdullahsisik@gmail.com
• Phone: +905327252381

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• See how nasal ondansetron compares to IV in healthy adults

  This study tests whether a nasal spray form of ondansetron delivers similar blood levels as the IV version in healthy adults.

  Recruiting Phase 1 Nasus Pharma · Jerusalem · NCT07868861

• Postoperative nausea, vomiting and pain after bariatric surgery in Sweden

  This study looks at how often people have nausea, vomiting, and pain after bariatric surgery in Sweden and whether anesthesia type or regional blocks affect those outcomes.

  Recruiting at 2 sites Umeå University · Sundsvall and 1 other locations · NCT07797374

• Time to first rescue antiemetic after two dual-drug regimens for PONV in gallbladder surgery

  This trial tests whether ondansetron plus metoclopramide delays the need for rescue antiemetic more than dexamethasone plus metoclopramide in adults at moderate-to-high risk undergoing laparoscopic cholecystectomy.

  Recruiting Phase 4 Faisalabad Medical University · Faisalābad, Punjab Province · NCT07638527

• Comfort Tote to help recovery after scoliosis surgery in teens

  This study tests whether a therapeutic Comfort Tote can reduce pain and anxiety after surgery for adolescent idiopathic scoliosis.

  Recruiting Columbia University · New York, New York · NCT07632833

• Menstrual cycle effects on optic nerve sheath diameter during laparoscopic gynecologic surgery

  This study will try to see if menstrual cycle phase changes the optic nerve sheath size and affects postoperative nausea, vomiting, and thinking in women having elective laparoscopic gynecologic surgery.

  Recruiting Konya City Hospital · Konya · NCT07539831

• High- vs low-dose propofol to reduce nausea after coronary bypass

  We will see if giving higher-dose propofol during coronary artery bypass surgery reduces postoperative nausea and vomiting in adults having elective CABG.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Outside of the US · NCT07386379

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.