Pancreatic tumors: using SMI and 2D-SWE-EUS to help tell PA from other solid lesions
Official title: Superb Microvascular Imaging (SMI) and Two-Dimensional Endoscopic Ultrasound Guided Shear Wave Elastography (2D-SWE-EUS) in Differential Diagnosis of Pancreatic Adenocarcinoma (PA) From Other Pancreatic Solid Lesions (PSLs) and Pancreatic neuroendocrinE Tumors (pNETs) Malignancy
Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT07274657 · Data updated 2026-11-12
This study tests whether combining Superb Microvascular Imaging and 2D-SWE-EUS can help doctors differentiate pancreatic adenocarcinoma from other solid pancreatic lesions in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | GCS Ramsay Santé pour l'Enseignement et la Recherche Academic / other |
| Locations | 1 site (Lyon) |
| Status | Recruiting |
| Started | February 24, 2026 |
| Main results expected | June 30, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07274657 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a diagnosed pancreatic solid lesion (including cystic component ≤25%) who can understand French and provide informed consent.
✕Probably not a fit
Patients whose lesions are clearly benign or whose imaging does not change clinical management may not gain direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Pancreatic adenocarcinoma is the most common pancreatic solid tumor and distinguishing it from other lesions is critical for treatment decisions. The study uses two imaging techniques—SMI and two-dimensional shear wave elastography guided by endoscopic ultrasound—to improve tumor characterization. Participants undergo these imaging modes during EUS as part of their diagnostic workup. The trial explores how these imaging features perform in differentiating PA from other pancreatic solid lesions, potentially reducing the need for invasive sampling. The study is conducted at a single French center with adults who have pancreatic solid lesions and meet eligibility criteria.
Why it matters
Potential benefit: If successful, patients may receive more accurate noninvasive imaging guidance to distinguish PA from other pancreatic lesions, guiding timely and appropriate management.
How similar studies have gone: Previous imaging approaches have shown promise in differentiating pancreatic lesions, but the combination of SMI and 2D-SWE-EUS is relatively novel in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient, male or female, age ≥ 18 years old * Patient with diagnosed pancreatic solid or mixed (cystic component ≤25 % of tumor volume) lesion * Patient with adequate understanding of written and spoken French, able to sign written informed consent * Patient affiliated with a social security system Exclusion Criteria: * Pregnant or breastfeeding woman * Patient with usual contraindications to EUS- TA * Patient with usual contraindications to SonoVue® administration * Patient with a genetic syndrome associated pancreatic lesion (multiple neuroendocrine neoplasia type 1 (MEN1), type 1 neurofibromatosis (NF), Von-Hippel Lindau (VHL) disease) * Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision. * Patient unable to perform the monitoring
Where it's running
-
Hôpital Privé Jean Mermoz
Lyon, France Recruiting
Study contacts
- Study coordinator: Rodica Gincul, MD
- Email: rodica_h13@yahoo.fr
- Phone: + 33 6 15 34 08 69
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.