Pain management after mastectomy with reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a paravertebral block in managing postoperative pain in women undergoing unilateral mastectomy with immediate reconstruction. The focus is on reducing the incidence of post-mastectomy pain syndrome (PMPS), which can lead to chronic neuropathic pain. Participants will receive either the paravertebral block or usual analgesia to compare outcomes related to pain relief. The study seeks to identify the best approach to minimize acute pain immediately after surgery, potentially reducing the risk of developing PMPS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-70 years of age
* woman scheduled for unilateral mastectomy with immediate reconstruction

Exclusion Criteria:

* Patients who will have an axillary dissection during surgery.
* Woman with severe hepatic insufficiency (Child Pugh Classification B and above24).
* Woman with kidney failure stage 4 and above25.
* Body mass index (BMI) \> 40 kg/m2.
* Woman with an allergy to local anesthetics.
* Woman with a bleeding disorder in whom BPV is contraindicated.
* Woman in whom stopping antiplatelet or anticoagulant therapy does not allow compliance with the standards of practice of neuraxial anesthesia issued by the American Society of Regional Anesthesia.
* Woman with a single lung.
* Pregnant woman.

Where it's running

• CHU de Quebec - Universite Laval
  Québec, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Jean-Charles Hogue
• Email: jean-charles.hogue@crchudequebec.ulaval.ca
• Phone: 418-525-4444

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

• Natural Biopolymer-Based Irrigant for Root Canal Cleaning

  This trial tests a chitosan nanoparticle irrigant to improve cleaning and disinfection in single-rooted teeth with asymptomatic pulp necrosis undergoing endodontic treatment.

  Recruiting Minia University · Minya · NCT07901127

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.