Ozonized gel vs low-level laser for healing gums after gingivectomy
Effect of Ozonized Gel Compared to Photobiomodulation Therapy on Wound Healing Following Surgical Gingivectomy : A Randomized Controlled Clinical Trial
Researchers will see if applying ozonized gel or using low-level laser (photobiomodulation) after gingivectomy helps adults heal faster and with less pain.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Alexandria University Academic / other |
| Locations | 1 site (Alexandria) |
| Trial ID | NCT07234994 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial will compare wound healing after surgical gingivectomy across three groups: ozonized hydrogel application, photobiomodulation with a 635 nm diode laser, and a control group receiving standard postoperative care. Forty-eight wound sites will be randomized equally, with treatments given immediately post-op and repeated on days 3, 7, and 14, and clinical follow-ups on days 3, 7, 14, and 28 to record healing and pain. Outcome measures include clinical wound healing assessments, patient-reported pain and feedback, and routine postoperative examinations. Adults aged 18–40 with good oral hygiene and adequate keratinized tissue are eligible, while smokers, pregnant women, and those with systemic conditions affecting healing are excluded.
Who should consider this trial
Good fit: Adults 18–40 indicated for surgical gingivectomy with good oral hygiene, adequate keratinized tissue, non-smokers, and able to follow postoperative instructions are ideal candidates.
Not a fit: Smokers, pregnant patients, people with systemic diseases affecting wound healing, or those with poor oral hygiene are unlikely to match the trial's eligibility and may not benefit.
Why it matters
Potential benefit: If successful, the preferred treatment could shorten healing time and reduce postoperative pain after gingivectomy.
How similar studies have performed: Previous dental research has reported that both ozonized products and photobiomodulation can aid tissue repair and pain control, but direct head-to-head comparisons after gingivectomy are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients indicated for surgical gingivectomy. 2. Adequate amount of keratinized tissue. 3. Average age between 18-40 years. 4. Well-educated patients as post-operative instructions need to be followed precisely. 5. Good oral hygiene with a full mouth O'Leary plaque index of less than or equal to 10% and a full mouth Gingival Index of zero Exclusion Criteria: 1. History of smoking. 2. Patients who have any known systemic disease that interfere with performance of surgical gingivectomy or periodontal wound healing. 3. Patients who have any previous adverse reactions to the products (or similar products) used in this study. 4. Pregnant women.
Where this trial is running
Alexandria
- Faculty of Dentistry, Alexandria University — Alexandria, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.