Outcomes for people with chronic kidney disease and obstructive sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a long-term observational cohort enrolling adults with stage 3–4 CKD who are not on dialysis. Participants will be screened for obstructive sleep apnea and followed over time to record kidney function, clinical events, and quality-of-life measures. The study aims to determine OSA prevalence, describe epidemiologic features, and identify demographic and clinical risk factors associated with OSA and renal decline. Findings are intended to inform earlier identification, diagnosis, and intervention for OSA in the CKD population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Voluntarily sign the informed consent form;

  * Aged ≥ 18 years and \< 75 years;
  * Patients with CKD stages 3-4, with an eGFR of 15-60 ml/min/1.73m² calculated using the CKD-EPI formula for at least 3 months.

Exclusion Criteria:

* Patients receiving oxygen therapy or continuous positive airway pressure (CPAP) treatment;

  * Patients with other sleep disorders, including restless legs syndrome, periodic limb movement disorder, etc.;
  * Patients with other severe comorbidities: Severe heart failure (NYHA class III or IV); Myocardial infarction, unstable angina, or stroke within the past 3 months; Severe arrhythmias requiring medication or device therapy; Respiratory diseases, including COPD, asthma, thoracic deformities, etc.; Neurological disorders, including myasthenia gravis, Parkinson's disease, Alzheimer's disease, etc.; Active liver disease or severe hepatic insufficiency; Psychiatric conditions, including depression, anxiety disorders, etc.; History of malignancy within the past 5 years (except cured basal cell carcinoma); Uncontrolled hyperthyroidism;
  * Patients who underwent surgery or had acute infections within the past 3 months;
  * Current heavy alcohol consumption:Females: \>3 drinks/day or \>7 drinks/week; Males: \>4 drinks/day or \>14 drinks/week (1 standard drink = 14g of alcohol)
  * Current use of medications that may severely interfere with sleep, such as antipsychotics, antiepileptics, antiparkinsonian drugs, antidepressants, opioids, etc.;
  * Females who are pregnant or lactating at screening or baseline;
  * Inability to comply with the study due to: Low education level, language barriers, inability to tolerate or complete sleep monitoring, or other reasons preventing completion of study procedures (e.g., follow-up);
  * Deemed unsuitable for participation by the investigator's judgment.

Where it's running

• Nanfang Hospital, Southern Medical University
  Guangzhou, Guangdong, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.