Clinical trial Recruiting at 1 site Observational

Osteochondritis Dissecans of the Knee: A Long-Term Observational Cohort

Official title: ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee

Run by University of Pennsylvania · NCT02771496 · Data updated 2026-11-12

This study follows people with knee OCD to see how the condition progresses and what treatments work over many years.

More Osteochondritis Dissecans trials

Quick facts

Study typeObservational
SexAll
Enrollment3000 (estimated)
SponsorUniversity of Pennsylvania
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedMay 1, 2014
Main results expectedMay 1, 2074
Study endsDecember 1, 2074
Registry record updatedMay 27, 2026
Trial IDNCT02771496 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Individuals with a diagnosis of knee osteochondritis dissecans confirmed by x-ray or MRI and who can commit to long-term follow-up.

Probably not a fit

Patients whose condition heals quickly or who do not experience meaningful changes may see no direct benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multi-site prospective cohort study enrolling patients with knee osteochondritis dissecans confirmed by imaging. Participants are followed for up to 50 years, with periodic quality of life and activity surveys and documentation of treatments and outcomes. No experimental intervention is given; care remains directed by the treating clinician. Surveys are completed at baseline and at 2, 5, 10, and 25 years, with options for remote completion when in-clinic visits are not possible. The goal is to understand disease courses, treatment options, and sports-related outcomes in athletic individuals.

Why it matters

Potential benefit: If successful, the study could clarify long-term outcomes and inform best practices for managing knee OCD.

How similar studies have gone: Previous observational cohorts have provided important insights, but long-term knee OCD-specific data remain limited and this study aims to expand that knowledge base.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI

Exclusion Criteria:

* Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)

Where it's running

  • University of Pennsylvania
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.