Osteochondritis Dissecans of the Knee: A Long-Term Observational Cohort
Official title: ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee
Run by University of Pennsylvania · NCT02771496 · Data updated 2026-11-12
This study follows people with knee OCD to see how the condition progresses and what treatments work over many years.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | May 1, 2014 |
| Main results expected | May 1, 2074 |
| Study ends | December 1, 2074 |
| Registry record updated | May 27, 2026 |
| Trial ID | NCT02771496 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Individuals with a diagnosis of knee osteochondritis dissecans confirmed by x-ray or MRI and who can commit to long-term follow-up.
✕Probably not a fit
Patients whose condition heals quickly or who do not experience meaningful changes may see no direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multi-site prospective cohort study enrolling patients with knee osteochondritis dissecans confirmed by imaging. Participants are followed for up to 50 years, with periodic quality of life and activity surveys and documentation of treatments and outcomes. No experimental intervention is given; care remains directed by the treating clinician. Surveys are completed at baseline and at 2, 5, 10, and 25 years, with options for remote completion when in-clinic visits are not possible. The goal is to understand disease courses, treatment options, and sports-related outcomes in athletic individuals.
Why it matters
Potential benefit: If successful, the study could clarify long-term outcomes and inform best practices for managing knee OCD.
How similar studies have gone: Previous observational cohorts have provided important insights, but long-term knee OCD-specific data remain limited and this study aims to expand that knowledge base.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI Exclusion Criteria: * Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)
Where it's running
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University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: James L Carey, MD — University of Pennsylvania
- Study coordinator: Mounika Ponakala, MS
- Email: mounika.ponakala@pennmedicine.upenn.edu
- Phone: 6093343767
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Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.