Oral skin supplement vs placebo to see if it improves aging skin in adults
Official title: A Double-Blind, Randomized, Double-Dummy, Active and Placebo-Controlled Clinical Study to Assess the Effect of an Oral Skin Supplement on Skin Health in Healthy Adults
Run by Amazentis SA · NCT07740824 · Data updated 2026-11-12
This study tests whether an oral skin supplement can improve signs of facial aging in healthy adults aged 35–65 compared with placebo.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 35 Years to 65 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Amazentis SA Industry-sponsored |
| Locations | 1 site (Bangalore, Karnataka) |
| Status | Recruiting |
| Started | August 26, 2026 |
| Main results expected | September 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT07740824 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 35–65 with visible facial skin aging signs who are in good health and willing to take the study products daily for 8 weeks and undergo skin biopsies and blood draws.
✕Probably not a fit
Participants who do not show biomarker or skin improvements or who cannot tolerate the interventions may not receive a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares an oral skin supplement to placebo over 8 weeks in adults with visible facial aging. Participants are randomly assigned to receive either the active SoftGel or matching placebo, with an active comparator powder and placebo powder as part of a double-dummy design. The study includes daily product use, two minimally invasive arm skin biopsies, and blood sampling to monitor aging biomarkers, safety labs, and general health. Eligible individuals are adults 35–65 in good health with visible aging signs who agree to avoid new anti-aging products during the trial. Primary outcomes focus on biomarker changes related to skin aging, along with safety and tolerability data.
Why it matters
Potential benefit: If successful, participants may experience improvements in skin aging biomarkers and related skin health indicators.
How similar studies have gone: Prior studies of similar oral skin supplements have shown variable effects on aging biomarkers, with some indicating potential benefit and others showing minimal change.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male and female trial participants in the age group of 35 -65 years, both ages inclusive. 2. Trial participants in good general health, as determined by the Investigator based on medical history, physical examination, vital signs, and clinical laboratory evaluations (CBC, LFT, and RFT). 3. Trial participants presenting with visible signs of facial skin aging, as assessed by the Investigator. 4. Trial participants willing to consume the assigned study products daily for 8 weeks in accordance with the study protocol. 5. Trial participants must be willing to undergo two minimally invasive skin biopsies collected from the upper arms. 6. Trial participants must be willing to provide blood samples for plasma collection and laboratory Investigations. 7. Trial participants willing to refrain from initiating any new skin care products, oral supplements, or anti-aging treatments during the study. 8. Trial participants willing to maintain their permitted and restricted skincare, diet, and lifestyle habits throughout the study. 9. Trial participants free of excessive hair, acne, cuts, abrasions, fissures, wounds, lacerations, or any other active skin conditions on the face and upper arms as determined by the dermatologist. 10. Trial participants who agree not to have direct and excessive sun exposure (not more than half an hour daily and during that time use of umbrella to cover face and upper arms). 11. Trial participants willing to refrain from bleaching or any other procedures including facial etc. on face during the study period. 12. Trial participants willing to give a voluntary written informed consent, photography release and agree to come for regular follow-up. 13. Trial participants willing to abide by and comply with study protocol. Exclusion Criteria: 1. Trial participants with known allergy, hypersensitivity, or intolerance to the study products or any of their ingredients, which, in the opinion of the Investigator, may impact participant safety, skin condition, or study outcomes. 2. Trial participants with clinical non-significant laboratory values or clinically significant findings in CBC, LFT, or RFT that, in the opinion of the Investigator, may affect participant safety or study participation. 3. Trial participants with a history or presence of clinically significant systemic diseases, including cardiovascular, immunological, vascular, hepatic, gallbladder, renal, or other uncontrolled medical disorders that, in the opinion of the Investigator, may interfere with study participation or study assessments. 4. Trial participants with active dermatological conditions on the face, including eczema, psoriasis, rosacea, acne, dermatitis, infections, wounds, sunburn, scars, or other skin disorders that may interfere with study assessments. 5. Trial participants who have used anti-aging treatments or procedures, including retinoids, isotretinoin, topical, systemic, injectable, or device-based therapies, within 3 months prior to screening. 6. Trial participants currently taking any medication that, in the opinion of the Investigator, may affect study results or interfere with study participation. 7. Trial participants who have undergone facial cosmetic procedures or aesthetic treatments, including chemical peels, laser treatments, dermabrasion, microneedling, botulinum toxin injections, dermal fillers, or similar procedures within 3 months prior to screening. 8. Trial participants currently using or having used within 1 month prior to screening oral supplements or medications known to influence skin appearance or aging (e.g., collagen supplements, biotin, antioxidant supplements, or investigational products). 9. Trial participants with a history of keloid formation, hypertrophic scarring, poor wound healing, bleeding disorders, or active skin infection, inflammation, wounds, or other abnormal skin conditions at or near the planned biopsy site. 10. Trial participants with a known bleeding disorder or current use of anticoagulant/antiplatelet medications that may interfere with blood collection. 11. Trial participants who have participated in another similar clinical trial within 3 months prior to screening. 12. Female trial participants who are pregnant, breastfeeding, or planning pregnancy during the study period. 13. Trial participants with a history of smoking, current smoking, use of smokeless tobacco products, or a history of or ongoing alcohol or recreational drug abuse. 14. Trial participants who are employees of the Sponsor, Contract Research Organization (CRO), or study site directly involved in the conduct of the study. 15. Trial participants judged by the Investigator to be unsuitable for participation for any reason that may compromise participant safety, protocol compliance, or study integrity.
Where it's running
-
MS Clinical Research Pvt. Ltd
Bangalore, Karnataka, India Recruiting
Study contacts
- Study coordinator: Anurag Singh, MD PhD
- Email: asingh@timeline.com
- Phone: +41215221274
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.