Oral Lactulose to Help GI Recovery After Complicated Appendicitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this single-center, triple-blind, randomized study, adults undergoing appendectomy for complicated appendicitis will receive lactulose or a placebo on postoperative days 1 and 2. The main goal is to see how long it takes until the patient can tolerate solids or have their first bowel movement (GI-2). Secondary outcomes include time to first flatulence, 72-hour defecation rate, nausea/vomiting, length of hospital stay, costs, complications, and any lactulose-related side effects. Researchers will enroll 150 participants and compare outcomes between the two groups to determine if early oral lactulose can promote faster gastrointestinal recovery. The trial is designed to provide high-quality evidence to guide postoperative care in this setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1.Age ≥18 years.2.Complicated appendicitis confirmed by SAS2.0 score, intraoperative findings, or pathology.3.Undergoing appendectomy (open or laparoscopic).4.Able to provide informed consent and comply with follow-up.

Exclusion Criteria:

* 1.Preoperative intestinal obstruction, IBD, or intestinal tumor.2.Planned postoperative fasting \>48 hours.3.Hypersensitivity to lactulose or placebo.4.Severe organ dysfunction (ASA ≥IV).5.Pregnancy or lactation.6.Cognitive or psychiatric disorder impairing follow-up.

Where it's running

• Beijing Anzhen Hospital Nanchong Hospital Affiliated to Capital Medical University, Nanchong, Sichuan 637000
  Sichuan, China Recruiting

Study contacts

• Study coordinator: Tian YunHong
• Email: drtianyunhong@126.com
• Phone: 86+13508087719

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.