Oral fiber supplementation for patients receiving stem cell transplants
Official title: Feasibility of Implementing Sustained Oral Fiber Supplementation for Patients Undergoing Treatment for Hematological Malignancies
Run by Fred Hutchinson Cancer Center · NCT04829136 · Data updated 2026-11-12
This study is testing if taking extra fiber can help people getting stem cell transplants feel better and improve their gut health during treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Fred Hutchinson Cancer Center Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Seattle, Washington) |
| Status | Recruiting |
| Started | June 22, 2022 |
| Main results expected | July 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | September 1, 2026 |
| Trial ID | NCT04829136 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are scheduled for allogeneic stem cell transplantation.
✕Probably not a fit
Patients with major psychiatric diagnoses that impair cognitive functioning or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of sustained oral fiber supplementation in patients undergoing donor stem cell transplantation for hematological malignancies. The study aims to improve nutrition and gut function in patients who often experience gastrointestinal damage due to chemotherapy, radiotherapy, or graft-versus-host disease. Participants will receive fiber supplementation starting 14 to 5 days prior to their conditioning chemotherapy and continuing until discharge, with follow-up assessments at 42, 60, and 90 days post-transplant. Blood samples will also be collected throughout the study to monitor health outcomes.
Why it matters
Potential benefit: If successful, this approach could enhance nutritional support and gut health for patients undergoing stem cell transplants, potentially leading to better recovery outcomes.
How similar studies have gone: Previous studies have explored nutritional interventions in similar patient populations, indicating potential benefits, but this specific approach is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to provide written informed consent prior to initiation of any study procedures * Any diagnosed hematological malignancy * At least 18 years of age * Planned treatment at Fred Hutchinson Cancer Center and/or University of Washington Medical Center Exclusion Criteria: * Major psychiatric diagnosis that impairs cognitive functioning or is not controlled at the time of the approach, as judged by the patient's medical team * Pregnant or breastfeeding. Pregnancy test is obtained as part of pre-transplant evaluation in women of child-bearing potential at arrival to transplant and again within 7 days of conditioning and will be confirmed as negative by review of the chart
Where it's running
-
Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, United States Recruiting
Study contacts
- Principal investigator: David Fredricks — Fred Hutch/University of Washington Cancer Consortium
- Study coordinator: David Fredricks
- Email: dfredric@fredhutch.org
- Phone: 206-667-1935
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.