Optimizing ventilation techniques for newborn infants
Official title: Crossover Study of the Cerebral Blood Flow and Cardiac Output At Different Targeted Tidal Volumes During High Frequency Oscillation with Volume Targeted Ventilation (HFO&VTV)
Run by King's College Hospital NHS Trust · NCT06719284 · Data updated 2026-11-12
This study is testing a new breathing method for newborns needing help with their lungs to see if it is safer than the usual method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 22 Weeks to 1 Year |
| Sex | All |
| Enrollment | 27 (estimated) |
| Sponsor | King's College Hospital NHS Trust Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | February 26, 2025 |
| Main results expected | September 1, 2026 |
| Study ends | September 1, 2026 |
| Registry record updated | March 10, 2025 |
| Trial ID | NCT06719284 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are newborn infants of any gestation who are receiving high-frequency oscillatory ventilation.
✕Probably not a fit
Patients with known intracerebral pathology or congenital cardiac abnormalities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates a new method of mechanical ventilation called high-frequency oscillation with volume-targeted ventilation (HFO&VTV) for newborn infants requiring respiratory support. The trial aims to compare the safety profile of HFO&VTV against traditional high-frequency oscillatory ventilation (HFOV) by measuring blood flow velocity to the brain and cardiac output in term infants. A total of 25 infants will be recruited, and they will receive different tidal volumes of gas in a randomized order while being monitored for carbon dioxide levels. The study seeks to establish guidelines for the use of HFO&VTV in clinical practice.
Why it matters
Potential benefit: If successful, this approach could reduce lung injury and protect against brain injury in newborn infants requiring mechanical ventilation.
How similar studies have gone: While high-frequency oscillation has been studied, the specific combination of HFO&VTV is novel and has not been extensively tested in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: -Newborn infants of any gestation receiving high frequency oscillatory ventilation Exclusion Criteria: * Infants with known intracerebral pathology (stroke, hydrocephalus, intracerebral hemorrhage, severe hypoxic ischemic encephalopathy). * Infants with congenital cardiac abnormalities.
Where it's running
-
King's College Hospital
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Theodore Dassios, Professor — King's College Hospital NHS Trust
- Study coordinator: Ourania Kaltsogianni, MSc
- Email: ourania.kaltsogianni@nhs.net
- Phone: 0044+02032999000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.