Optimizing screening for early detection of familial pulmonary fibrosis
Optimising Screening for Early Disease Detection in Familial Pulmonary Fibrosis
This study is testing how well current screening methods work for detecting familial pulmonary fibrosis in family members of patients to find better ways to spot it early.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Antonius Hospital Academic / other |
| Locations | 1 site (Nieuwegein) |
| Trial ID | NCT05367349 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effectiveness of current screening parameters for familial pulmonary fibrosis (FPF) by examining 200 first-degree relatives of patients diagnosed with FPF. The study aims to understand the natural progression of early FPF and determine the optimal intervals for screening visits. By focusing on easily operable screening parameters, the research seeks to develop an evidence-based protocol that could potentially shift some screening activities to general practice. The ultimate goal is to enhance early detection and timely therapeutic support for at-risk individuals.
Who should consider this trial
Good fit: Ideal candidates for this study are asymptomatic first-degree relatives of patients with familial pulmonary fibrosis.
Not a fit: Patients with a previous diagnosis of interstitial lung disease or those who are minors or pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection of familial pulmonary fibrosis, allowing for timely interventions that may slow disease progression.
How similar studies have performed: While this study focuses on a specific familial context, similar approaches in early disease detection have shown promise in other conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Asymptomatic first-degree relative of patients with familial pulmonary fibrosis (FPF) Exclusion Criteria: * A previous diagnosis of interstitial lung disease (ILD) * Minors (aged \<18 years) * Pregnant Note: woman who are pregnant at the start of the study or at the time of the HRCT are not allowed to participate. If a participant gets pregnant at a later stage during the study, she will not be excluded from the study. To be able to account for a potential effect of pregnancy during data analysis, female participants can be asked if they are pregnant at every visit.
Where this trial is running
Nieuwegein
- St Antonius Hospital — Nieuwegein, Netherlands (Recruiting)
Study contacts
- Study coordinator: Jan Grutters, Prof.
- Email: j.grutters@antoniusziekenhuis.nl
- Phone: +31883201453
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.