Optimizing remote treatment for obesity

Evaluating the EVO Treatment Optimized for Resource Constraints: Elements Vital to Treat Obesity.

NA · Northwestern University · NCT04708769

This study is testing a new mobile health program for weight loss against a standard diabetes prevention program to see which one helps people lose weight better over six months.

Quick facts

PhaseNA
Study typeInterventional
Enrollment524 (estimated)
Ages18 Years to 70 Years
SexAll
SponsorNorthwestern University (other)
Locations1 site (Chicago, Illinois)
Trial IDNCT04708769 on ClinicalTrials.gov

What this trial studies

This study evaluates a newly optimized mobile health intervention for obesity against the established Diabetes Prevention Program (DPP) in a randomized controlled trial. Participants will be assigned to either the APP, which utilizes a smartphone application for self-monitoring and biweekly sessions with a Health Promotionist, or the DPP, which involves guided sessions and participant logs for tracking weight and activity. The study aims to assess weight-loss success and cost-effectiveness over a 24-week intervention period, with follow-up assessments at 3, 6, and 12 months.

Who should consider this trial

Good fit: Ideal candidates are adults with a BMI between 30 and 45 who are stable in weight and own a smartphone.

Not a fit: Patients currently enrolled in formal weight loss programs or those with certain medical conditions, such as diabetes requiring insulin, will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective and accessible method for managing obesity through mobile health technology.

How similar studies have performed: Other studies have shown promise in using mobile health interventions for weight management, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* BMI 30-45
* Weight stable
* Own a Smartphone and be willing to install our Smartphone app
* Willing to conduct video conference calls with study staff

Exclusion Criteria:

* Enrolled in any formal weight loss program
* Taking anti-obesity medications
* Not taking medications that may cause weight gain
* Unstable medical conditions
* Diabetes requiring insulin supplementation
* Crohn's Disease
* Diagnosis of obstructive sleep apnea requiring intervention (i.e., CPAP)
* Assistive devices for mobility
* Hospitalizations for a psychiatric disorder within the past 5 years
* Cardiovascular disease symptoms while performing moderate intensity exercise
* Pregnancy, trying to get pregnant, or lactating.
* Bulimia or binge eating disorder
* Reports of active suicidal ideation
* Current substance abuse or dependence besides nicotine dependence

Where this trial is running

Chicago, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Obesity, Weight Loss, Diet, Physical Activity, Self Monitoring, Mobile Health

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.