Optimizing postoperative therapy for cervical cancer using MRD screening

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the safety and efficacy of a combined treatment approach involving chemoradiotherapy and immunotherapy for patients with early postoperative cervical cancer. It focuses on using MRD (Minimal Residual Disease) screening to detect and monitor changes in MRD status throughout treatment, aiming to improve prognosis and recurrence monitoring. The study is structured into three periods: screening, treatment, and follow-up, with participants categorized into high-risk and intermediate-risk groups based on specific criteria. Treatment regimens vary according to risk classification, incorporating conventional therapies and immunotherapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with histopathological and clinical (FIGO 2018) stage ⅠB2 \~II A2 cervical cancer.
2. Above the age of 18.
3. General status: ECOG score 0-2.
4. Be able to understand the research scheme, voluntarily participate in the study, and sign the informed consent.
5. Good compliance, able to cooperate with the collection of specimens at each node and provide corresponding clinical information.

Exclusion Criteria:

1. Suffering from other malignant tumors.
2. Do not receive the specified treatment or change the treatment regimen before the disease progresses.
3. The study cannot be followed up according to the defined clinical follow-up period.
4. Unable to accept or provide CT or other designated therapeutic evaluation means.
5. Have an autoimmune disease.

Where it's running

• The Affiliated Suzhou Hospital of Nanjing Medical University
  Suzhou, Jiangsu, China Recruiting

Study contacts

• Principal investigator: jing xue — The Affiliated Suzhou Hospital of Nanjing Medical University
• Study coordinator: jing xue
• Email: jxue@njmu.edu.cn
• Phone: (+86)13771734347

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.