Optimizing lymphatic pumping to boost flu vaccine response in older or overweight adults
Official title: Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
Run by Lake Erie College of Osteopathic Medicine · NCT07786467 · Data updated 2026-11-12
This study tests whether a specific osteopathic manipulation technique can help people, especially older adults or those with higher body fat, produce a stronger antibody response to the seasonal influenza vaccine.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Lake Erie College of Osteopathic Medicine Academic / other |
| Locations | 1 site (Erie, Pennsylvania) |
| Status | Recruiting |
| Started | September 2026 |
| Main results expected | October 2027 |
| Study ends | October 2027 |
| Registry record updated | September 23, 2026 |
| Trial ID | NCT07786467 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years and older who are willing to receive both the influenza vaccine and osteopathic manipulative treatment.
✕Probably not a fit
Individuals who do not mount a stronger antibody response or who do not benefit from the osteopathic protocol may not experience improvement in vaccine response.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study will compare an osteopathic manipulative treatment protocol to a sham procedure to see if it enhances antibody titers after influenza vaccination. Participants are adults 18 and older who are willing to receive the vaccine and osteopathic manipulative treatment, including those who are older or have higher adiposity. The study focuses on immune responses in healthy volunteers without a specific disease being studied. It is conducted at Plaza 38 Medical Offices in Erie, Pennsylvania, led by Lake Erie College of Osteopathic Medicine.
Why it matters
Potential benefit: If successful, participants may achieve a stronger antibody response to the influenza vaccine, potentially improving protection against flu.
How similar studies have gone: Previous work in related osteopathic or manual therapies has shown mixed results; this study tests a specific protocol in a defined population and its success remains to be established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Willing to receive OMT * Willing to receive influenza vaccine * Older than 18 years of age Exclusion Criteria: * Younger than 18 years of age * Pregnancy or lactation * Unwilling to receive the influenza vaccine * Unwilling to receive OMT * Open wounds * Bone fractures * Moderate to severe osteoporosis * Severe COPD * Current/active infections * Mononucleosis infection within past 6 months * Liver cirrhosis * Cancer or metastatic disease * History of DVT, PE, or blood clotting disorder * Individuals taking blood thinning medications, except aspirin * Having a pacemaker or other thoracic medical devices
Where it's running
-
Plaza 38 Medical Offices
Erie, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: David Duriancik, Ph.D. — Lake Erie College of Osteopathic Medicine
- Study coordinator: David Duriancik, Ph.D.
- Email: dduriancik@lecom.edu
- Phone: 814-860-5139
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
French Contrast Training vs Oregon Circuit Training for Explosive Power in Competitive Football Players
This trial tests whether French Contrast Training or Oregon Circuit Training better improves explosive power, leg strength, and agility in competitive football players aged 16–25.
-
K-Savvy: Supporting Korean American Dementia Caregivers Online
A online program called K-Savvy helps Korean American caregivers of loved ones with dementia manage stress and depression.
-
Low-dose atomoxetine to see how noradrenaline changes learning and decision-making
This study will test whether a low dose of atomoxetine changes how healthy adults learn and update decisions during tasks that measure evidence accumulation.
-
Improving performance and reducing risks for esports athletes through ergonomic protocols
This study is testing a special program to see if it can help esports athletes perform better and reduce their risk of injury while gaming.
-
Fisetin absorption and clearance in young versus older adults
This test will measure how a single oral dose of fisetin is absorbed and cleared in healthy young adults (18–30) and older adults (65+) when taken fasting or with a high‑fat meal.
-
Using mental imagery to enhance non-technical skills in anaesthesia residents
This study tests if using mental imagery exercises can help anaesthesia residents improve their decision-making, communication, and teamwork skills during neonatal resuscitation training.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.