Opiranserin plus acetaminophen vs NSAIDs plus acetaminophen after minimally invasive gallbladder removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, non-inferiority study in adults undergoing minimally invasive cholecystectomy. Participants are assigned 1:1 to receive either opiranserin plus acetaminophen or acetaminophen plus NSAIDs to manage postoperative pain. The trial aims to compare analgesic efficacy and safety between the two regimens. No details on sample size or statistical endpoints are provided. The study is sponsored by Gangnam Severance Hospital in Seoul.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient undergoing minimally invasive cholecystectomy

Exclusion Criteria:

* Known hypersensitivity or allergy to acetaminophen, NSAIDs, opiranserin, or fentanyl.
* pre-existing chronic pain,
* clinically significant ECG findings (QRS \> 200 msec, QTcF \>450 msec)
* severe renal impairment
* severe hepatic impairment

Where it's running

• Gangnam Severance Hospital
  Seoul, South Korea Recruiting
• Gangnam Severance Hospital
  Seoul, South Korea Not yet recruiting

Study contacts

• Study coordinator: Young Song
• Email: NEARMYHEART@yuhs.ac
• Phone: 02-2019-6692

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Robotic versus laparoscopic gallbladder removal for benign gallbladder disease

  This trial will test whether robotic gallbladder removal is as safe as standard laparoscopic surgery for adults who need their gallbladder removed for benign disease.

  Recruiting Portsmouth Hospitals NHS Trust · Portsmouth · NCT07119203

• Improvised retrieval bag vs direct gallbladder extraction in laparoscopic cholecystectomy

  This trial tests whether using an improvised retrieval bag to remove the gallbladder during laparoscopic cholecystectomy is as safe and effective as removing it directly without a bag in adults with gallbladder stones.

  Recruiting Rawal Institute of Health Sciences Islamabad · Islamabad, Federal · NCT07823803

• Recto-Intercostal and External Oblique Intercostal Blocks for Pain after Laparoscopic Gallbladder Removal

  This trial tests whether adding a recto-intercostal fascial plane block to an existing external oblique intercostal plane block provides better pain relief after laparoscopic cholecystectomy in adults.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07777172

• Dexamethasone, Dexmedetomidine, or Both After Laparoscopic Gallbladder Surgery

  This study tests whether dexamethasone, dexmedetomidine, or the combination help recovery of gut function after laparoscopic cholecystectomy.

  Recruiting Benha University · Banhā · NCT07329933

• Versius robotic gallbladder removal: how well it works in adults

  This study tests whether the Versius robotic system can safely and effectively perform gallbladder removal in adults without needing to switch to another method.

  Recruiting at 2 sites CMR Surgical Ltd · Los Angeles, California and 2 other locations · NCT07096856

• Gallbladder removal versus watchful waiting after bile duct stone removal in older adults

  This trial tests whether immediate laparoscopic gallbladder removal or a wait-and-see approach is better for older patients after their common bile duct stones have been removed by ERCP.

  Recruiting at 2 sites Helsinki University Central Hospital · Espoo and 11 other locations · NCT07001423

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.