Opioid-Free Anesthesia to Improve Early Recovery After Thyroid Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, interventional trial compares an opioid-free anesthesia (OFA) scheme with a conventional balanced anesthesia during elective thyroidectomy. The OFA protocol uses dexamethasone, flurbiprofen, dexmedetomidine, lidocaine, esketamine, and propofol with BIS guidance to maintain anesthesia, aiming to reduce opioid exposure. Primary outcome centers on QoR-15 scores in the early postoperative period, with safety and rationality of OFA monitored closely. Eligible participants are adults (18+) with ASA I–II undergoing elective thyroidectomy, without chronic opioid or NSAID use and without major comorbidities. The study is conducted at Beijing Friendship Hospital, Capital Medical University.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Patients undergoing elective thyroidectomy under general anesthesia
* \>18 year old
* The informed consent form has been signed
* American Society of Anesthesiologists (ASA) anesthesia grade I - II

Exclusion Criteria:

* Long term use of opioids
* Long term use of NSAIDs
* Have a history of psychosis, epilepsy, preoperative anxiety, depression, and emotional management disorders
* Patients with increased gastric contents reflux and respiratory tract aspiration
* Operation time\>3h
* Severe liver and kidney insufficiency, cardiac insufficiency, bradycardia with 2 ° II or 3° atrioventricular block
* Those who are allergic to or have contraindications to drugs that may be used in the test
* Those who cannot cooperate with researchers

Where it's running

• Beijing Friendship Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Haijun Hou — Guang'anmen Hospital of China Academy of Chinese Medical Sciences
• Study coordinator: Haijun Hou
• Email: lumen208@foxmail.com
• Phone: +8618612568228

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.