Online memory intervention for people with traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness and feasibility of an online spatial navigation intervention aimed at improving memory and brain health in individuals with moderate to severe traumatic brain injury. Participants will engage in a structured program that involves learning new routes and creating mental maps for one hour a day, five days a week over 16 weeks. The study will compare outcomes between those participating in the intervention and an active control group watching educational videos. Assessments will include MRI scans and cognitive measures focused on memory and spatial navigation before and after the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* acute care diagnosis of m-sTBI
* PTA of 24 hours or more and/or lowest GCS \<13
* positive CT or MRI; (4) between 18 to 55 years of age
* fluency in English; (6) competency to provide informed consent or availability of a legal decision maker
* basic computer skills (use of internet/email, mouse and arrow keys)
* functional use of at least one upper extremity for computer use
* resident of Greater Toronto Area (to facilitate access to the MRI).

Exclusion Criteria:

* neurological disorder other than TBI (e.g., dementia, stroke)
* diagnosis of a neurodevelopmental disorder
* TBI sustained before age 18
* systemic comorbidities (e.g., lupus, diabetes)
* current diagnosis of aphasia
* presence of metal inside the body (e.g., surgical clips, pacemaker) leading to ineligibility for an MRI.

Where it's running

• Toronto Rehabilitation Institute
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Robin E Green, PhD; CPsych — Toronto Rehabilitation Institute
• Study coordinator: Kadeen Johns, BA
• Email: kadeen.johns@uhn.ca
• Phone: 416-597-3422

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.