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Observing how anesthesiologists manage hemodynamic disorders during rapid sequence intubation

Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study. The Crush or Crash Study.

Nantes University Hospital · NCT06194058

This study looks at how anesthesiologists in France handle blood pressure and heart rhythm problems during quick intubation in adult patients to see if there are ways to make anesthesia safer.

Quick facts

Study typeObservational
Enrollment1150 (estimated)
Ages18 Years and up
SexAll
SponsorNantes University Hospital (other)
Locations42 sites (Amiens and 41 other locations)
Trial IDNCT06194058 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the clinical practices of French anesthesiologists regarding the prevention and management of severe hemodynamic disorders during rapid sequence anesthetic induction in adult patients. It will collect data on the occurrence of major hemodynamic events, such as significant drops or spikes in mean blood pressure and sustained arrhythmias. The study will involve multiple centers to provide a comprehensive overview of current practices and adherence to expert recommendations. By analyzing these practices, the study seeks to identify areas for improvement in patient safety during anesthesia.

Who should consider this trial

Good fit: Ideal candidates for this study are adult patients aged 18 and older who require general anesthesia with oro or nasotracheal intubation and are indicated for rapid sequence induction.

Not a fit: Patients who may not benefit from this study include those under 18 years old, those with impossible intubation planned, or those in preoperative respiratory distress or shock.

Why it matters

Potential benefit: If successful, this study could enhance the safety and effectiveness of rapid sequence intubation, reducing the risk of hemodynamic complications in patients.

How similar studies have performed: While there is variability in practices, this study aims to fill a gap in current literature, suggesting that it may provide novel insights rather than building on previously established findings.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥ 18 years' old
* Procedure requiring general anesthesia with oro or nasotracheal intubation
* Anesthetic management with indication of rapid sequence induction
* No objection after oral and written information to the patient

Exclusion Criteria:

* Age \< 18 years' old
* Impossible intubation planned
* Preoperative respiratory distress (SpO2 \< 90% in ambient air)
* Preoperative shock (MBP≤ 65 mmHg or vasopressive amines)
* Preoperative coma defined by a Glasgow score ≤ 12/15
* Patient in cardiopulmonary arrest
* Patients under guardianship or curatorship

Where this trial is running

Amiens and 41 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Rapid Sequence Intubation, anesthetic induction, adult patients, hemodynamic disorders, arrythmia, cardiac arrest, pre-oxygenation, mean blood pressure

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.