Observing cognitive impairment in older adults
Cognitive Impairment in Ageing People: A Longitudinal Observational Prospective Study
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · NCT04360200
This study looks at older adults to see how mild cognitive impairment and dementia develop, hoping to find better ways to prevent and treat these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (other) |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT04360200 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding mild cognitive impairment (MCI) and neurocognitive disorders such as Alzheimer's disease and vascular dementia in elderly populations. It aims to establish a prospective cohort to gather comprehensive epidemiological data and biological samples, which will aid in early prevention, diagnosis, and treatment of cognitive disorders. The study will utilize gene and brain imaging biomarkers to enhance the understanding of dementia pathogenesis and improve targeted interventions. By addressing the rising burden of dementia in China, the study seeks to provide valuable insights into this public health issue.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals over 50 years old who show signs of mild cognitive impairment but do not meet the full criteria for dementia.
Not a fit: Patients with severe mental illness, significant physical disabilities, or those who refuse necessary examinations may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early diagnosis and treatment strategies for cognitive impairments in the elderly.
How similar studies have performed: Other studies focusing on cognitive impairment and dementia have shown promise in utilizing biomarkers for diagnosis and intervention, indicating that this approach is supported by previous research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients over 50 years old. 2. Sign informed consent. 3. According to DSM-IV, the diagnostic standard of dementia was not met. 4. The clinical dementia rating (CDR) was 0.5. Exclusion criteria: 1. Subjects with mental retardation. 2. Refuse to have blood sampling, imaging and other examinations. 3. Uncooperative subjects that have serious organic diseases, or have a history of mental illness, or have physical disability (including severe aphasia). 4. Contraindications of MR scanning. 5. Suffering from serious physical or mental illness.
Where this trial is running
Guangzhou, Guangdong
- Sun Yat-sen Memorial Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China (RECRUITING)
Study contacts
- Study coordinator: Yamei Tang
- Email: yameitang@hotmail.com
- Phone: +86-020-34070569
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: MCI, Alzheimer Disease, VAD - Vascular Dementia, Cognitive Impairment