Observing bone and mineral disorders in patients
A Natural History Study of Bone and Mineral Disorders
This study is looking at people with bone and mineral disorders to see how their conditions affect them and to collect information that can help with future research.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 1 Day to 100 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Trial ID | NCT00024804 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate participants with various bone and mineral disorders at the NIH Clinical Center. It focuses on collecting tissue and clinical specimens from individuals with known or suspected skeletal diseases, including tumor-induced osteomalacia and familial tumoral calcinosis. Participants will undergo standard medical evaluations, including physical exams and imaging tests, to gather data that may stimulate further research in bone biology. The study also aims to create a database of information from enrolled participants to support future clinical research.
Who should consider this trial
Good fit: Ideal candidates include individuals of any age with known or suspected bone diseases or disorders of mineral metabolism.
Not a fit: Patients without any known or suspected bone or mineral metabolism disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding and treatment of bone and mineral disorders, leading to improved patient outcomes.
How similar studies have performed: Other studies focusing on the natural history of skeletal diseases have shown promise, indicating that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: The study population will include participants with known or suspected bone disease and/or with a known or suspected disorder of mineral metabolism. To be eligible to participate in this study, an individual must meet all of the following criteria: 1. Age 1 day of life or older 2. Have a known or suspected bone disease, as demonstrated by any one of the following: a fracture, or abnormal bone findings on x-ray, CT scan, MRI, or bone densitometry, and/or a medical or family history consistent with or suggestive of a bone disease. 3. Have a known or suspected disorder of mineral metabolism, as demonstrated by any one of the following: laboratory measurement above or below the reference values for either blood or urine calcium, phosphorus, magnesium, parathyroid hormone or vitamin D, or other measures of mineral metabolism, and/or a medical or family history consistent with or suggestive of a disorder of mineral metabolism. EXCLUSION CRITERIA: 1\. Participants unwilling or unable to abide by the procedures of the protocol.
Where this trial is running
Bethesda, Maryland
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Kelly B Roszko, M.D. — National Institute of Dental and Craniofacial Research (NIDCR)
- Study coordinator: Elizabeth A Ferguson
- Email: elizabeth.ferguson@nih.gov
- Phone: (240) 687-3029
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.