Clinical trial Recruiting at 16 sites Observational Ages 40 and up

Observing antithrombotic drug effects in ischemic stroke patients with microbleeds

Official title: Antithrombotic Drug Use in Patients With Ischemic Stroke and Microbleeds

Run by Xijing Hospital · NCT05032053 · Data updated 2026-11-12

This study is testing how different blood-thinning medications affect recovery in people who have had ischemic strokes and have small brain bleeds.

Quick facts

Study typeObservational
Ages40 Years and up
SexAll
Enrollment3000 (estimated)
SponsorXijing Hospital
Academic / other
Locations16 sites (Ankang, Shaanxi and 15 other locations)
StatusRecruiting
StartedMarch 1, 2022
Main results expectedDecember 1, 2027
Study endsDecember 1, 2027
Registry record updatedJuly 30, 2026
Trial IDNCT05032053 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients aged 40 and older who have been clinically diagnosed with ischemic stroke within the last three months.

Probably not a fit

Patients with symptomatic intracranial hemorrhage or significant bleeding lesions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to observe the effects of various antithrombotic drugs on the prognosis of patients who have experienced ischemic strokes and have cerebral microbleeds. It will involve a cohort registration study to track the progress of these patients over one year while receiving different antithrombotic therapies. Additionally, the study will utilize data independent acquisition quantitative proteomics to identify serum protein markers that may predict patient outcomes. The goal is to enhance understanding of safe and effective antithrombotic therapy for this specific patient population.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for ischemic stroke patients with microbleeds, potentially reducing the risk of complications.

How similar studies have gone: While the approach of using proteomics in this context is relatively novel, previous studies have indicated potential risks associated with antithrombotic drugs in similar patient populations.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients diagnosed clinically as ischemic stroke;
2. Age ≥ 40 years;
3. Onset time ≤ 3 months;
4. Informed consent was signed.

Exclusion Criteria:

1. Patients with symptomatic intracranial hemorrhage;
2. bleeding lesion \> 10 mm was found on SWI;
3. Vascular malformations, tumors, abscesses or other major non ischemic brain diseases were present;
4. There are contraindications for antithrombotic drugs use;
5. Serious systemic diseases;
6. Refusal to sign informed consent or poor compliance.

Where it's running

  • Ankang Central Hospital
    Ankang, Shaanxi, China
    Recruiting
  • 3201 Hospital
    Hanzhong, Shaanxi, China
    Recruiting
  • Department of Neurology, Xijing Hospital, Fourth Military Medical University
    Xi'an, Shaanxi, China
    Recruiting
  • Yan'an University Affiliated Hospital
    Ya'an, Shaanxi, China
    Recruiting
  • Yulin No.2 Hospital
    Yunlin, Shaanxi, China
    Recruiting
  • Xi'AN GAOXIN Hospital
    Xi'an, Shannxi, China
    Recruiting
Show 10 more locations
  • Hanzhong People's Hospital
    Hanzhong, China
    Recruiting
  • 986 Hospital
    Xi'an, China
    Recruiting
  • Gaoling District Hospital
    Xi'an, China
    Recruiting
  • Gem Flower Xi'an Changqing Staff Hospital
    Xi'an, China
    Recruiting
  • Tangdu Hospital
    Xi'an, China
    Recruiting
  • The First Affiliated Hospital of Xi'an Medical University
    Xi'an, China
    Recruiting
  • No.215 Hospital of Shaanxi nuclear industry
    Xianyang, China
    Recruiting
  • The First People's Hospital of Xianyang
    Xianyang, China
    Recruiting
  • Xian Yang Central Hospital
    Xianyang, China
    Recruiting
  • Yan'an People's Hospital
    Yan’an, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

    This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

    Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

  • Remote ischemic conditioning for post-stroke insomnia

    A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.

    Recruiting Sichuan Academy of Medical Sciences · Chengdu, Sichuan · NCT07874594

  • Ear-based nerve stimulation to help sleep after a stroke

    A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.

    Recruiting Casa Colina Hospital and Centers for Healthcare · Pomona, California · NCT07858656

  • Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)

    This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.

    Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle · NCT07834333

  • Preventing another ischemic stroke with a smart bracelet and app

    This study tests whether a digital prevention program using a wearable and a mobile app can help people who recently had an ischemic stroke reduce the chance of another stroke and improve risk-factor control.

    Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07825311

  • Photon-counting CT to check intracranial stents

    This study tests whether ultra-high-resolution photon-counting CT can reliably visualize intracranial stents and detect in-stent restenosis during follow-up of patients with prior stents.

    Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07769814

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.