Observing antithrombotic drug effects in ischemic stroke patients with microbleeds
Official title: Antithrombotic Drug Use in Patients With Ischemic Stroke and Microbleeds
Run by Xijing Hospital · NCT05032053 · Data updated 2026-11-12
This study is testing how different blood-thinning medications affect recovery in people who have had ischemic strokes and have small brain bleeds.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Xijing Hospital Academic / other |
| Locations | 16 sites (Ankang, Shaanxi and 15 other locations) |
| Status | Recruiting |
| Started | March 1, 2022 |
| Main results expected | December 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | July 30, 2026 |
| Trial ID | NCT05032053 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients aged 40 and older who have been clinically diagnosed with ischemic stroke within the last three months.
✕Probably not a fit
Patients with symptomatic intracranial hemorrhage or significant bleeding lesions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to observe the effects of various antithrombotic drugs on the prognosis of patients who have experienced ischemic strokes and have cerebral microbleeds. It will involve a cohort registration study to track the progress of these patients over one year while receiving different antithrombotic therapies. Additionally, the study will utilize data independent acquisition quantitative proteomics to identify serum protein markers that may predict patient outcomes. The goal is to enhance understanding of safe and effective antithrombotic therapy for this specific patient population.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for ischemic stroke patients with microbleeds, potentially reducing the risk of complications.
How similar studies have gone: While the approach of using proteomics in this context is relatively novel, previous studies have indicated potential risks associated with antithrombotic drugs in similar patient populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients diagnosed clinically as ischemic stroke; 2. Age ≥ 40 years; 3. Onset time ≤ 3 months; 4. Informed consent was signed. Exclusion Criteria: 1. Patients with symptomatic intracranial hemorrhage; 2. bleeding lesion \> 10 mm was found on SWI; 3. Vascular malformations, tumors, abscesses or other major non ischemic brain diseases were present; 4. There are contraindications for antithrombotic drugs use; 5. Serious systemic diseases; 6. Refusal to sign informed consent or poor compliance.
Where it's running
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Ankang Central Hospital
Ankang, Shaanxi, China Recruiting -
3201 Hospital
Hanzhong, Shaanxi, China Recruiting -
Department of Neurology, Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China Recruiting -
Yan'an University Affiliated Hospital
Ya'an, Shaanxi, China Recruiting -
Yulin No.2 Hospital
Yunlin, Shaanxi, China Recruiting -
Xi'AN GAOXIN Hospital
Xi'an, Shannxi, China Recruiting
Show 10 more locations
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Hanzhong People's Hospital
Hanzhong, China Recruiting -
986 Hospital
Xi'an, China Recruiting -
Gaoling District Hospital
Xi'an, China Recruiting -
Gem Flower Xi'an Changqing Staff Hospital
Xi'an, China Recruiting -
Tangdu Hospital
Xi'an, China Recruiting -
The First Affiliated Hospital of Xi'an Medical University
Xi'an, China Recruiting -
No.215 Hospital of Shaanxi nuclear industry
Xianyang, China Recruiting -
The First People's Hospital of Xianyang
Xianyang, China Recruiting -
Xian Yang Central Hospital
Xianyang, China Recruiting -
Yan'an People's Hospital
Yan’an, China Recruiting
Study contacts
- Study coordinator: Wen Jiang, Ph.D
- Email: jiangwen@fmmu.edu.cn
- Phone: 86-029-84771319
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.
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This study tests whether a digital prevention program using a wearable and a mobile app can help people who recently had an ischemic stroke reduce the chance of another stroke and improve risk-factor control.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.