Observational study on preschool wheezing biomarkers
Development of Non-invasive Biomarkers to Direct Individualised Management of Preschool Wheeze
Imperial College London · NCT06237660
This study is trying to find easy tests for preschool kids with wheezing to see what’s causing it, like allergies or infections, so doctors can make better treatment choices.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 1 Year to 5 Years |
| Sex | All |
| Sponsor | Imperial College London (other) |
| Locations | 1 site (London) |
| Trial ID | NCT06237660 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on preschool children aged 1-5 years who experience wheezing, a condition that accounts for a significant portion of childhood hospitalizations in the UK. The research aims to identify simple, non-invasive bedside tests that can accurately determine the underlying causes of wheezing in these children, such as allergies or infections. Participants will undergo various tests, including skin prick tests, finger prick blood tests, and sputum samples, to evaluate their feasibility and accuracy in guiding treatment decisions. The study also seeks to assess parental willingness to participate in a treatment-guided trial based on test results.
Who should consider this trial
Good fit: Ideal candidates for this study are preschool children aged 1-5 years who have experienced multiple hospitalizations for wheezing.
Not a fit: Patients with alternative respiratory diagnoses, such as cystic fibrosis or bronchiectasis, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized treatments for preschool children with wheezing, improving their health outcomes.
How similar studies have performed: While this approach is novel in its specific application to preschool wheezing, similar studies have shown promise in identifying biomarkers for respiratory conditions in other populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Aim 1, 2 and 3: * Children aged 1-5 years * More than 2 hospitalisations for acute wheeze in the last year or * At least 1 admission requiring high dependency unit or intravenous bronchodilator therapy in the last year. Aim 1 only: \- children undergoing clinically indicated bronchoscopy, as determined by their existing medical team, as part of their standard management Exclusion Criteria: * Alternative respiratory diagnosis such as cystic fibrosis or bronchiectasis.
Where this trial is running
London
- Royal Brompton Hospital — London, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Sejal Saglani, MD — Imperial College London
- Study coordinator: Cheuk Fung Wong
- Email: cheuk-fung.wong@imperial.ac.uk
- Phone: +4420 7594 9832
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Wheezing, Preschool wheeze, Preschool asthma, Allergy, Infection, Steroids