Observational study on outcomes after hip and knee replacements

QIST Collaborative - Arthroplasty Research Cohort (ARC) Study - a Collaborative, Longitudinal Observational Cohort Study of Patients Undergoing Primary Hip and Knee Replacements in the United Kingdom

Observational Northumbria Healthcare NHS Foundation Trust · NCT05824845

This study looks at how people feel and do after getting hip and knee replacements to find ways to improve their care in the future.

Quick facts

Study typeObservational
Enrollment5000 (estimated)
Ages18 Years and up
SexAll
SponsorNorthumbria Healthcare NHS Foundation Trust Academic / other
Locations1 site (Ashington)
Trial IDNCT05824845 on ClinicalTrials.gov

What this trial studies

The ARC Study is a national observational cohort study aimed at investigating patient-reported and clinical outcomes following hip and knee replacements. It evaluates outcomes, identifies risk factors for adverse outcomes, and seeks to establish targets for future research and interventions. Participants are recruited online and through outpatient clinics, providing a resource for identifying potential participants for future clinical trials. The study collects data that can serve as comparison or control data for randomized trial participants.

Who should consider this trial

Good fit: Ideal candidates are UK residents aged 18 and over who are undergoing elective primary hip or knee arthroplasty.

Not a fit: Patients who do not meet the inclusion criteria or are not undergoing elective hip or knee replacements may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve understanding of outcomes and risks associated with hip and knee replacements, leading to better patient care.

How similar studies have performed: Other studies have shown success in similar observational approaches, indicating the potential for valuable insights.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

Participants must meet all of the inclusion criteria:

1. UK Resident
2. Able to read and understand documentation and questionnaires in English language
3. Undergoing elective primary hip or knee arthroplasty (THR, TKR or UKR)
4. Age 18 years or over
5. Provides the necessary consents relating to data collection and use of study data, data linkage, future research and invitation to involvement in future trials

Exclusion Criteria:

Provided a participant meets all of the inclusion criteria, there are no exclusion criteria for the cohort study.

Where this trial is running

Ashington

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Hip ArthritisKnee ArthritisHip ReplacementKnee Replacement
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.