Observational study on adult hemophagocytic lymphohistiocytosis
A Prospective Cohort for Subjects With Adult Hemophagocytic Lymphohistiocytosis Like Syndrome
This study is looking at adults with hemophagocytic lymphohistiocytosis to learn more about their symptoms and how they respond to treatments like immunosuppressive therapy or chemotherapy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 81 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Samsung Medical Center Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Seoul) |
| Trial ID | NCT03117010 on ClinicalTrials.gov |
What this trial studies
This observational study enrolls adults who exhibit clinical and laboratory signs of hemophagocytic lymphohistiocytosis (HLH). Participants will undergo a thorough evaluation based on established HLH criteria and may receive systemic immunosuppressive therapy or chemotherapy as part of their treatment. The study aims to gather data on the clinical and biological characteristics of HLH in adults, with regular monitoring by participating physicians. The findings could enhance understanding and management of this serious condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who meet the diagnostic criteria for hemophagocytic lymphohistiocytosis.
Not a fit: Patients who do not meet the diagnostic criteria for HLH or are under 18 years old will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the diagnosis and treatment strategies for patients with hemophagocytic lymphohistiocytosis.
How similar studies have performed: While there have been studies on HLH, this specific observational approach focusing on adult patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Subjects should fulfill the following criteria
1. Subjects should have at least one of the following problems
1. Presence of hemophagocytosis in tissue or bone marrow
2. Presence of at least 3 conditions among 8 conditions of HLH diagnostic criteria
2. Age \> 18 years
3. Written informed consents
Exclusion Criteria:
* Subjects cannot satisfy the inclusion criteria
Where this trial is running
Seoul
- Samsung Medical Center — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Seok Jin Kim, MD, PhD — Samsung Medical Center
- Study coordinator: Seok Jin Kim, MD, PhD
- Email: kstwoh@skku.edu
- Phone: +82234101766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.