Observational study on adult hemophagocytic lymphohistiocytosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study enrolls adults who exhibit clinical and laboratory signs of hemophagocytic lymphohistiocytosis (HLH). Participants will undergo a thorough evaluation based on established HLH criteria and may receive systemic immunosuppressive therapy or chemotherapy as part of their treatment. The study aims to gather data on the clinical and biological characteristics of HLH in adults, with regular monitoring by participating physicians. The findings could enhance understanding and management of this serious condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects should fulfill the following criteria

  1. Subjects should have at least one of the following problems

     1. Presence of hemophagocytosis in tissue or bone marrow
     2. Presence of at least 3 conditions among 8 conditions of HLH diagnostic criteria
  2. Age \> 18 years
  3. Written informed consents

     Exclusion Criteria:
* Subjects cannot satisfy the inclusion criteria

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Seok Jin Kim, MD, PhD — Samsung Medical Center
• Study coordinator: Seok Jin Kim, MD, PhD
• Email: kstwoh@skku.edu
• Phone: +82234101766

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• National Egyptian HLH Registry for pediatric patients

  A national HLH registry is being created in Egypt to collect information about pediatric HLH patients to improve understanding and care.

  Recruiting Ain Shams University · Cairo and 1 other locations · NCT07800234

• Using ruxolitinib with a modified HLH-94 regimen to treat hemophagocytic lymphohistiocytosis.

  This study is testing if a new combination of ruxolitinib and a modified treatment plan can help adults newly diagnosed with hemophagocytic lymphohistiocytosis feel better and live longer.

  Recruiting at 4 sites Phase 2 University of California, San Francisco · Irvine, California and 3 other locations · NCT06160791

• Understanding treatment outcomes in lymphoma-related hemophagocytic lymphohistiocytosis

  This study looks at how people with lymphoma who develop a serious condition called hemophagocytic lymphohistiocytosis are treated and what the outcomes are, to find better ways to help them survive.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05898477

• Validation of the OHI Index for Hematologic Malignancies

  This study is testing a new index to see if it can help doctors better understand and predict outcomes for patients with blood cancers who might develop a serious condition called HLH.

  Recruiting at 2 sites Meir Medical Center · Kfar Saba and 1 other locations · NCT05882175

• Registry for patients with Hemophagocytic Lymphohistiocytosis

  This study is collecting information from patients with Hemophagocytic Lymphohistiocytosis to better understand the condition and improve future treatments.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT05277272

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.