Observational study of patients with recent ischemic stroke
Official title: Prospective Cohort With Incident Stroke
Run by Ludwig-Maximilians - University of Munich · NCT01364168 · Data updated 2026-11-12
This study is trying to see if new ways to predict the risk of having another stroke, heart attack, or dying can help people who have just had their first ischemic stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 850 (estimated) |
| Sponsor | Ludwig-Maximilians - University of Munich Academic / other |
| Locations | 2 sites (Berlin and 1 other locations) |
| Status | Recruiting |
| Started | February 2011 |
| Main results expected | December 2024 |
| Study ends | December 2027 |
| Registry record updated | March 19, 2024 |
| Trial ID | NCT01364168 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have experienced their first acute ischemic stroke within the last 7 days and can provide informed consent.
✕Probably not a fit
Patients with a history of prior strokes, brain tumors, or those participating in other intervention studies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to derive and validate risk scores for vascular endpoints such as recurrent stroke, myocardial infarction, and death following an incident stroke. Approximately 850 patients who have experienced their first acute ischemic stroke will be followed for 36 months, with assessments at baseline and at 3, 12, 24, and 36 months. The study will evaluate known predictors of vascular diseases and incorporate new biomarkers, including neuroimaging and blood-based markers, to improve predictive models. The models will be validated using bootstrap methods and an independent external sample from a related cohort.
Why it matters
Potential benefit: If successful, this study could provide improved risk assessment tools for patients who have suffered an ischemic stroke, potentially leading to better management and outcomes.
How similar studies have gone: Other studies have shown success in developing prognostic models for stroke outcomes, but this study aims to enhance existing models with new biomarkers, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Language: German * First ever acute ischemic stroke that occurred with stroke onset in the last 7 days * Written informed consent by patient prior to study participation * Willingness to participate in follow-up Exclusion Criteria: * Prior stroke (definition according to WHO criteria) * Patients presenting brain tumour or brain metastasis * Participation in an intervention- / AMG-study
Where it's running
-
Interdisciplinary Stroke Center Munich, Klinikum der Universität München
Munich, Germany Recruiting -
Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin
Berlin, Germany Active not recruiting
Study contacts
- Study coordinator: Martin Dichgans, Prof.
- Email: martin.dichgans@med.uni-muenchen.de
- Phone: +49 (0)89 4400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.