Observational study of HIV-1 infected individuals and their responses to treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

SCOPE is an observational study that collects clinical data and biological samples from HIV-1 infected volunteers to investigate various factors related to HIV infection and treatment. The study focuses on understanding the natural control of HIV-1, disease progression, and the evolution of drug resistance. Participants are seen at San Francisco General Hospital every four months for interviews, saliva collection, and blood draws, with a strong emphasis on maintaining confidentiality of personal identifiers. The collected specimens will be used for future research on virologic and immunologic responses to HIV.

Why it matters

Who can join: the full rules

Inclusion Criteria:

SCOPE is currently recruiting HIV-1 infected subjects with any of the following criteria:

1. Documented HIV viral load less than 2000 copies/ml WITHOUT taking antiretroviral therapy
2. Undetectable HIV viral load with CD4 T-cells consistently less than 350 for the last 12 months while taking a stable antiretroviral regimen.
3. Antiretroviral naive and planning to start an antiretroviral regimen - any CD4 or HIV viral load acceptable.
4. Long-term Non Progressors: HIV-positive at least 10 years, no antiretroviral therapy for the past 10 years or more, any viral load acceptable, CD4-T cell count always above 500.

Exclusion Criteria:

1. Active opportunistic infection or systemic treatment for opportunistic infection within the last 4 months (oral candidiasis acceptable)
2. Active treatment for cancer
3. Active treatment for hepatitis C requiring interferon based therapy
4. Immunosuppressive therapy taken within the last 4 months

Where it's running

• San Francisco General Hospital
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Steven G. Deeks, M.D. — University of California, San Francisco
• Study coordinator: Rebecca Hoh, M.S., R.D.
• Email: Rebecca.Hoh@ucsf.edu
• Phone: 415-476-4082

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.