Observational look at antimicrobial resistance in people with chronic lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects baseline demographics, medical history, treatments, and microbiology results from participants with chronic lung diseases. It includes two pathways: periodic prospective data collection from clinic attendees and in-depth clinical visits with sample collection for genomic analysis. Biological samples—sputum, nasal swabs, exhaled breath, blood, and remote stool—are analyzed to understand resistance patterns without using any intervention. Data are stored in a secure database and linked to clinical characteristics to explore associations with disease status and microbiology. The study is led by Imperial College London with Royal Brompton Hospital as the site, focusing on patients stratified by specific bacterial colonisation status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Presence of an underlying chronic lung disease (e.g. Bronchiectasis, COPD) stratified by colonisation status:

  * Pseudomonas sp (n=30)
  * Klebsiella sp (n=20)
  * Haemophilus sp (n=20)
  * E-coli sp (n=20)
  * Stenotrophomonas sp (n=20)
  * Staphylococcus sp (n=20)
  * Other chronic colonisation (n=20)
  * Not colonised with any bacterial pathogen (n=20)

Exclusion Criteria:

* Inability to provide informed consent
* Pregnancy
* Medical instability preventing ability to attend for regular study visits at baseline.

Where it's running

• Royal Brompton Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Anand Shah — Imperial College London
• Study coordinator: Anand Shah
• Email: s.anand@imperial.ac.uk
• Phone: 0044 20 7352 8121

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.