Nutritional supplement plus functional exercise to boost immunity and health in older adults
Official title: Effects of a Nutritional Supplement and Functional Exercise Program on Seasonal Immunity, Perceived Health, and Oxidative Stress in Older Adults
Run by University of Valencia · NCT07251244 · Data updated 2026-11-12
This project will see if taking a daily natural-origin supplement while doing supervised twice-weekly functional exercise for six months helps people 65 and older improve seasonal immune responses, reduce oxidative stress, and feel and function better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Valencia Academic / other |
| Locations | 1 site (Valencia, Valencia) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | July 2026 |
| Study ends | July 2026 |
| Registry record updated | December 22, 2025 |
| Trial ID | NCT07251244 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Independent adults aged 65 or older who can attend supervised exercise sessions, are not immunosuppressed, and do not regularly use antioxidant or immunomodulatory supplements.
✕Probably not a fit
People with active autoimmune disease, recent corticosteroid or immunosuppressive drug use, unstable cardiovascular conditions, active infection, or an inability to participate in moderate exercise are unlikely to receive benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, placebo-controlled trial will assign adults aged 65 and older to either a daily natural nutritional supplement or a matching placebo while all participants follow a supervised, moderate-intensity functional exercise program twice weekly for six months. Assessments occur before, midway, and after the intervention and include blood draws to measure immunological and oxidative stress biomarkers. Investigators will also collect data on physical function, physiological measures, and quality of life. Safety and adverse events will be monitored throughout the study.
Why it matters
Potential benefit: If successful, the combined supplement and exercise program could strengthen seasonal immune responses, lower oxidative stress, and improve perceived health and physical function in older adults.
How similar studies have gone: Moderate exercise is well documented to support immune function in older adults and some supplements reduce oxidative stress, but combined, double-blind randomized trials of supplement-plus-exercise are limited and have shown mixed results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 65 years or older * Functional independence, defined as the ability to perform activities of daily living without assistance * Sufficient cognitive capacity to understand instructions and complete questionnaires, assessed through interview or brief cognitive screening if necessary * Not immunosuppressed * Not regular users of antioxidant or immunomodulatory supplements * Ability and availability to attend exercise sessions and scheduled assessments throughout the six-month study period * Commitment to maintain stable dietary and physical activity habits during the intervention Exclusion Criteria: * Active autoimmune diseases or clinically relevant immunosuppression * Use of corticosteroids or immunosuppressive drugs in the 4 weeks prior to study initiation * Active infection or compatible symptoms (fever, cough, diarrhea) in the 2 weeks prior to any measurement * Unstable cardiovascular conditions or medical contraindications for moderate physical exercise * Moderate to severe cognitive impairment that prevents proper participation in the scheduled activities * Participation in another clinical trial in the last 3 months * Known allergy or hypersensitivity to the supplement or any of its excipients
Where it's running
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Physical activity and Sport Science Faculty, Valencia, Valencia
Valencia, Valencia, Spain Recruiting
Study contacts
- Study coordinator: Juan Carlos Colado Sánchez, Chair full professor
- Email: juan.colado@uv.es
- Phone: (9639) 83470
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.