Nutrition and gut metabolites in heart surgery patients
Nutritional Intervention in the Modulation of Postoperative Metabolism in Cardiovascular Surgery
This will try a postoperative probiotic supplement in people having cardiovascular surgery to see if changing gut-derived metabolites improves blood metabolic markers and recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | Fu Jen Catholic University Academic / other |
| Locations | 1 site (New Taipei City) |
| Trial ID | NCT07497932 on ClinicalTrials.gov |
What this trial studies
This interventional study will collect preoperative blood and intraoperative cardiac tissue to map gut microbiota-derived metabolites using targeted and untargeted mass spectrometry. A subset of participants will be randomized to receive postoperative probiotic supplementation or placebo, with serial blood draws to track metabolomic and microbiome changes. The design links tissue-level and circulating metabolite measurements with a nutritional intervention to probe the gut–heart metabolic axis. Clinical outcomes and metabolic profiles will be compared between the probiotic and placebo groups over follow-up.
Who should consider this trial
Good fit: Adults scheduled for cardiovascular surgery at the participating center who have completed preoperative evaluations, can give informed consent, and have not used antibiotics or probiotics in the past four weeks are ideal candidates.
Not a fit: Patients with recent antibiotic or probiotic use, or with major gastrointestinal disease, are less likely to benefit or may be excluded from the intervention.
Why it matters
Potential benefit: If successful, the intervention could improve postoperative metabolic profiles and clinical recovery by modulating gut-derived metabolites linked to cardiovascular risk.
How similar studies have performed: Emerging basic and observational research links gut microbiota metabolites to cardiovascular disease, but clinical trials directly testing postoperative probiotic modulation of cardiac tissue and circulating metabolites are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Scheduled to undergo cardiovascular surgery * Completed preoperative clinical and imaging evaluations * Willing to provide informed consent * Willing to receive potential probiotic supplementation Exclusion Criteria: * Use of antibiotics, probiotics, or other treatments affecting gut microbiota within 4 weeks * History of major gastrointestinal disease
Where this trial is running
New Taipei City
- Fu Jen Catholic University Hospital, Fu Jen Catholic University — New Taipei City, Taiwan (Recruiting)
Study contacts
- Principal investigator: Ke-Yun Chao, PhD — Fu Jen Catholic University
- Study coordinator: Ke-Yun Chao, PhD
- Email: C00152@mail.fjuh.fju.edu.tw
- Phone: +886-905-301-879
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.