NT-proBNP and cardiac markers to predict outcomes after vascular surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates whether cardiac biomarkers, especially NT-proBNP measured around the time of vascular surgery, can identify patients at higher risk of adverse outcomes such as heart attack or death. By analyzing pre- and post-operative biomarker levels, researchers aim to see if these markers improve risk stratification in elective vascular procedures. The findings could inform future strategies to reduce perioperative risk in high-risk patients. The study builds on prior work suggesting combined marker profiles may offer better prognostic value than any single biomarker alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who are equal to or over 18 years old
* Patients scheduled to undergo elective surgery for the following procedures:
* Infrainguinal arterial reconstruction
* Aortic aneurysm
* Aorto-bifemoral bypass / or aortic endarterectomy
* Femoro-popliteal bypass
* Femoro-distal bypass
* Femoral endarterectomy
* Femoro-femoral crossover
* Axillo-femoral bypass
* Elective carotid surgery
* Patients having either general or regional anaesthesia for their surgery

Exclusion Criteria:-

* Patients undergoing emergency surgery
* Those who are unable or unwilling to give informed consent
* Patients with unstable coronary syndromes (acute or recent MI with evidence of important ischemic risk by clinical symptoms or stress testing or unstable or severe angina pectoris)
* Patients with decompensated heart failure (new onset shortness of breath and rales together with echocardiographic evidence of cardiac dysfunction or deterioration of chronic heart failure despite heart failure therapy)
* Patients with chronic atrial fibrillation

Where it's running

• Norfolk & Norwich University Hospitals NHS Foundation Trust
  Norwich, Norfolk, United Kingdom Recruiting

Study contacts

• Principal investigator: Emma Miler, MSc BSc Hons — principle investigator
• Study coordinator: Emma Miler, MSc BSc Hons
• Email: emma.miler@nnuh.nhs.net
• Phone: +44(0)1603-286-932

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.