Normal 24-hour esophageal pH‑impedance values in healthy Indian adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center protocol will recruit healthy Indian volunteers aged 18–50 and record 24-hour ambulatory esophageal pH‑impedance monitoring. Participants without gastrointestinal symptoms or major systemic disease and with normal BMI will undergo sensor placement and continuous monitoring while usual meals, body positions, and sleep are recorded. The study will quantify acid exposure time (AET) and reflux episodes and analyze how diet, posture, and nocturnal periods affect these measures. The goal is to define population-specific normative cut-offs to improve GERD diagnosis in the Indian context.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult 18-50 years of age
* No gastro-intestinal symptoms
* No past GI or thoracic or spine surgery
* Not on any medications
* No history of recent alcohol intake (0 drinks in the past 1 month)
* Non smoker
* Normal BMI (18.5-22.9)

Exclusion Criteria:

* Any diagnosed systemic or organ specific disease (liver/kidney/heart/neurological disease, DM/HTN/Thyroid disease/ connective tissue disorder/inflammatory bowel disease/ irritable bowel syndrome)
* GERD symptoms/ functional dyspepsia
* Pregnant women or breast-feeding women
* Helicobacter pylori infection

Where it's running

• AIG hospitals
  Hyderabad, Telangana, India Recruiting

Study contacts

• Study coordinator: Krithi Krishna Doctor
• Email: drkrithivk@gmail.com
• Phone: +91 9870083545

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Quality sleep improvement with evening topical therapy for nocturnal GERD

  This trial tests a medical device given before bed to see if it reduces nighttime GERD symptoms and improves sleep and quality of life in adults with nocturnal reflux.

  Recruiting Cellmedis · Warsaw, Masovian Voivodeship and 1 other locations · NCT07700342

• Gerd symptoms with tegoprazan treatment in adults

  This study tests whether tegoprazan 50 mg (tablet or dispersible tablet) helps GERD symptoms and is safe in adults who meet criteria.

  Recruiting HK inno.N Corporation · Seoul · NCT07678177

• New topical treatment options for GERD symptoms

  This trial tests a medical device to see if it relieves GERD symptoms and improves quality of life in adults compared with a placebo.

  Recruiting Cellmedis · Warsaw, Masovian Voivodeship · NCT07624383

• Left-sided versus traditional bilateral laparoscopic repair for hiatal hernia with reflux

  This compares two laparoscopic operations—a left-sided approach and the traditional bilateral approach—to see which helps adults (18–85) with hiatal hernia whose reflux doesn't get better on usual acid‑reducing medicine.

  Recruiting Beijing Friendship Hospital · Beijing and 1 other locations · NCT07252115

• Improving GERD medication adherence using the GERDCare smartphone app

  This project will test whether the GERDCare smartphone app helps adults with GERD stick to their medications, diet, and lifestyle changes over four weeks.

  Recruiting Institute of Gastroenterology and Hepatology, Vietnam · Hanoi · NCT07125521

• How three ice-cream formulations affect esophageal movement in people with GERD or weak esophageal motility

  This test will try three specially made ice creams to see if they change how the esophagus moves in people with ineffective esophageal motility or GERD.

  Recruiting Federal State Budgetary Scientific Institution · Moscow · NCT07121803

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.