Norepinephrine vs Phenylephrine to Prevent Post-Spinal Hypotension in Older Adults Undergoing Hip Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, double-blinded study enrolling elderly patients (60 years and above) scheduled for elective hip surgery under spinal anesthesia. Participants will be assigned to receive prophylactic norepinephrine infusion or phenylephrine infusion immediately after spinal block, with primary outcome focusing on heart rate during vasopressor infusion. Secondary outcomes include incidence of hypotension, severe hypotension, bradycardia, reactive hypertension, intraoperative fluid needs, blood loss, transfusion requirements, and postoperative nausea and vomiting. The study aims to compare hemodynamic stability and safety between the two vasopressor strategies in an older population with ASA I–III status, conducted at Sohag University Hospitals after ethics approval.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 60 years or older.
2. ASA physical status I-III.
3. Scheduled for elective hip surgery under subarachnoid block.
4. Willing to provide written informed consent.

Exclusion Criteria:

1. Patient refusal.
2. Contraindications to subarachnoid block.
3. Severe cardiac disease.
4. Uncontrolled hypertension.
5. Allergy to study drugs.
6. Emergency surgery.
7. Monoamine oxidase inhibitor use.
8. Cognitive impairment preventing informed consent.

Where it's running

• Sohag university hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed Abdelhamed Faress, Resident
• Email: drahmedfaress23896@gmail.com
• Phone: 01065080913

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.