Non-Invasive Temporally Interfering Electric Fields Stimulation for Epilepsy and Healthy Adults
Official title: Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)
Run by University of California, Davis · NCT07663578 · Data updated 2026-11-12
This test will see if a non-surgical brain stimulation method called TIEFS can change brain activity and thinking skills in adults with epilepsy and in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Status | Recruiting |
| Started | April 16, 2025 |
| Main results expected | April 15, 2027 |
| Study ends | April 15, 2027 |
| Registry record updated | June 23, 2026 |
| Trial ID | NCT07663578 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Eligible adults aged 18-65 with epilepsy undergoing intracerebral monitoring or healthy adults without seizure history, who can consent and complete cognitive tasks.
✕Probably not a fit
Some participants may not experience cognitive benefits or may not tolerate stimulation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of Temporally Interfering Electric Fields Stimulation (TIEFS) on brain signals and cognitive functions. It includes adults with epilepsy undergoing intracerebral monitoring and healthy controls, comparing brain activity and performance on memory, attention, language, and movement tasks before and after brief TIEFS sessions. Researchers will monitor safety and tolerability while collecting electrophysiological data and cognitive outcomes. The trial uses scalp electrodes to deliver the stimulation without any invasive procedure. Participation requires English or Spanish fluency and the ability to consent and complete tasks.
Why it matters
Potential benefit: If successful, TIEFS could offer a non-invasive option to modulate brain activity and support cognitive function in epilepsy and possibly other populations.
How similar studies have gone: Prior non-invasive brain stimulation approaches have shown mixed but growing evidence of modulating brain activity and cognition in some populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (age 18-65 years of age) undergoing an intracerebral electrophysiology study for epilepsy pre-surgical evaluation are eligible for inclusion. * For healthy control subjects are also eligible for inclusion (Scalp EEG measurements). * Participants must be able to sufficiently speak and understand English or Spanish for consent and be able to understand and complete cognitive tasks. * All subjects must have the ability to give valid informed consent. Exclusion Criteria: * No pregnant women will be recruited. * People with implanted electrical devices such as Deep Brain Stimulation devices or Pacemakers. * No prisoners will be recruited.
Where it's running
-
University of California Davis Medical Center
Sacramento, California, United States Recruiting
Study contacts
- Principal investigator: Nigel P Pedersen, MBBS — University of California Davis, School of Medicine, Neurology Department
- Study coordinator: Nigel P Pedersen, MBBS
- Email: nppedersen@health.ucdavis.edu
- Phone: 617-462-8120
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.