Non-invasive neuromodulation for menstrual pain relief in women

Effectiveness of Non-invasive Neuromodulation in Primary Dysmenhorrea: A Randomized Clinical Trial

Phase 3 Interventional Escoles Universitaries Gimbernat · NCT06233786

This study is testing whether a non-invasive treatment using electrical nerve stimulation can help women with painful periods feel better during different phases of their menstrual cycle.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years and up
SexFemale
SponsorEscoles Universitaries Gimbernat Academic / other
Locations1 site (Torrelavega, Cantabria)
Trial IDNCT06233786 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in adult women suffering from primary dysmenorrhea. Participants will be divided into groups based on the timing of TENS application during their menstrual cycle: during the bleeding phase and the luteal phase. A control group will receive similar treatment without active TENS stimulation. Pain levels will be assessed using various scales before, immediately after, and at subsequent menstrual cycles to determine the efficacy of the intervention.

Who should consider this trial

Good fit: Ideal candidates are adult women with regular menstrual cycles and pain levels greater than 3 on the NPRS scale.

Not a fit: Patients who are pregnant, breastfeeding, or have specific gynecological or neurological conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a non-invasive and effective pain management option for women suffering from primary dysmenorrhea.

How similar studies have performed: Other studies have shown promise with TENS for pain management, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion criteria:

* Adult women
* Pain greater than 3 on the NPRS scale
* Women with regular menstrual cycle, considered regular between 25-30 days

Exclusion criteria:

* Pregnancy or breastfeeding
* Used of intrauterine device
* Diagnosed gynaecological pathology: endometriosis, polycystic ovaries, uterine fibroid, adenomyosis, fibrosis, uterine malformation, pelvic inflammation, scars, SDT...
* Skin lesions that prevent the placement of the electrodes
* Other diagnosed pathologies that contraindicate the application of TENS, neurological pathologies, or cardiovascular diseases
* Absence or doubling of bleeding in one month
* Taking analgesic medications and/or NSAIDs

Where this trial is running

Torrelavega, Cantabria

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Primary DysmenorrheaTranscutaneous Electrical Nerve StimulationNon-Invasive NeuromodulationSacral Surface Stimulation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.