Non-invasive methods to diagnose complications after liver transplantation
Official title: Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients
Run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05793203 · Data updated 2026-11-12
This study is testing new, non-invasive ways to spot complications early in people who have had a liver transplant to help improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Rome) |
| Status | Recruiting |
| Started | July 6, 2020 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | March 31, 2023 |
| Trial ID | NCT05793203 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients who are eligible for liver transplantation according to established guidelines.
✕Probably not a fit
Patients who are re-transplant candidates or those undergoing liver transplantation due to fulminant hepatitis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of non-invasive methods to identify postoperative complications in liver transplant recipients. It focuses on the early detection of acute cellular rejection and early allograft dysfunction by analyzing biological markers and instrumental assessments. The goal is to improve prognostic capabilities in the early post-transplant phase, addressing a significant gap in current diagnostic practices. By monitoring liver enzyme levels and function tests, the study aims to enhance patient outcomes following liver transplantation.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and management of complications in liver transplant patients, potentially improving their long-term outcomes.
How similar studies have gone: While there is ongoing research in this area, the specific non-invasive methods being explored in this study are novel and have not been extensively tested in similar contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients eligible for liver transplantation following National and International Guidelines Exclusion Criteria: * No agreement or inability to give informed consent * Re-transplant patients * Liver transplant in fulminant hepatitis
Where it's running
-
Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy Recruiting
Study contacts
- Study coordinator: Luca Miele, MD, PhD
- Email: luca.miele@policlinicogemelli.it
- Phone: +390630151
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.