Non-invasive methods to diagnose complications after liver transplantation
Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients
This study is testing new, non-invasive ways to spot complications early in people who have had a liver transplant to help improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Rome) |
| Trial ID | NCT05793203 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of non-invasive methods to identify postoperative complications in liver transplant recipients. It focuses on the early detection of acute cellular rejection and early allograft dysfunction by analyzing biological markers and instrumental assessments. The goal is to improve prognostic capabilities in the early post-transplant phase, addressing a significant gap in current diagnostic practices. By monitoring liver enzyme levels and function tests, the study aims to enhance patient outcomes following liver transplantation.
Who should consider this trial
Good fit: Ideal candidates for this study are patients who are eligible for liver transplantation according to established guidelines.
Not a fit: Patients who are re-transplant candidates or those undergoing liver transplantation due to fulminant hepatitis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and management of complications in liver transplant patients, potentially improving their long-term outcomes.
How similar studies have performed: While there is ongoing research in this area, the specific non-invasive methods being explored in this study are novel and have not been extensively tested in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients eligible for liver transplantation following National and International Guidelines Exclusion Criteria: * No agreement or inability to give informed consent * Re-transplant patients * Liver transplant in fulminant hepatitis
Where this trial is running
Rome
- Fondazione Policlinico Universitario A. Gemelli IRCCS — Rome, Italy (Recruiting)
Study contacts
- Study coordinator: Luca Miele, MD, PhD
- Email: luca.miele@policlinicogemelli.it
- Phone: +390630151
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.