Non-invasive assessment of kidney transplant condition using advanced imaging techniques
Non-invasive Evaluation of Graft Condition in Adult Patients With Kidney Transplant Using Ultrasound Localization Microscopy and Multispectral Optoacoustic Tomography
University of Erlangen-Nürnberg Medical School · NCT06472947
This study is testing new imaging techniques to see if they can help check the health of kidney transplants in adults without needing to do invasive biopsies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Erlangen-Nürnberg Medical School (other) |
| Locations | 1 site (Erlangen, Bavaria) |
| Trial ID | NCT06472947 on ClinicalTrials.gov |
What this trial studies
This study evaluates the condition of kidney transplants in adults through non-invasive methods, specifically using Multispectral Optoacoustic Tomography (MSOT) and Ultrasound Localization Microscopy (ULM). The goal is to identify new markers that can provide insights into transplant health, potentially reducing the need for invasive kidney biopsies. Given the high stakes of kidney health and the risks associated with biopsies, this approach aims to enhance patient care and monitoring. The study will involve adult participants who are already indicated for a biopsy as part of their routine clinical care.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients who have undergone kidney transplantation and are indicated for a biopsy based on clinical routine.
Not a fit: Patients who are not indicated for a biopsy or those with contraindications to the imaging techniques will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the need for invasive kidney biopsies, improving patient comfort and safety.
How similar studies have performed: While non-invasive imaging techniques have been explored, this specific application of MSOT and ULM in kidney transplant assessment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * kidney transplant * indication for biopsy set in clinical routine * minimum 18 years of age * written consent Exclusion Criteria: * allergy against contrast agents/ SonoVue * tatoos in examined areas * contraindication against SonoVue * pregnant women * breast feeding women
Where this trial is running
Erlangen, Bavaria
- Department of Pediatrics and Adolescent Medicine — Erlangen, Bavaria, Germany (RECRUITING)
Study contacts
- Principal investigator: Ferdinand Knieling, PD Dr. Dr. — FAU Erlangen-Nuremberg
- Study coordinator: Ferdinand Hannah Knieling, PD Dr. Dr.
- Email: ferdinand.knieling@uk-erlangen.de
- Phone: 0049 9131 85 33118
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Kidney Transplant, Kidney Biopsy