Non-contrast MRI tracking of kidney transplant function using donor baselines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, multicenter hybrid cohort study uses a standardized non-contrast functional MRI protocol (including DWI, ASL, BOLD, and MT sequences) to quantify renal perfusion, oxygenation, diffusion, and microstructure. The study enrolls paired donor-recipient sets where donors undergo pre-transplant MRI to create individualized baselines, plus an independent recipient cohort (primarily deceased-donor transplants) to validate MRI metrics without donor baselines. MRI measures will be integrated with body composition, metabolic profiles, and routine clinical and laboratory data to build models for early detection, treatment monitoring, and prognosis of graft function. Imaging and clinical data will be collected across multiple centers in China and analyzed for reproducibility and diagnostic performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adult participants (age ≥ 18 years).

For the Paired Donor-Recipient Cohort:

Donor: Scheduled for living kidney donation, OR is a deceased organ donor who can undergo a pre-transplant MRI.

Recipient: Recipient of a kidney transplant or simultaneous pancreas-kidney transplant from the paired donor.

For the Independent Recipient Cohort:

Recipient: Recipient of a kidney transplant from a deceased donor for whom donor baseline data is unavailable.

Able to provide informed consent.

Exclusion Criteria:

Any contraindication to MRI (e.g., cardiac pacemaker, non-MRI compatible metallic implants, neurostimulators, severe claustrophobia).

Inability to tolerate the breath-holding required for MRI acquisition.

Pregnancy.

Any clinical condition that, in the investigator's judgment, would severely compromise study participation or data integrity (e.g., uncontrolled severe infection, active major psychiatric illness).

Where it's running

• Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting
• Sinopharm Dongfeng General Hospital, Dongfeng Motor Corporation and Hubei University of Medicine.
  Shiyan, Hubei, China Not yet recruiting
• Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University
  Taiyuan, Shanxi, China Not yet recruiting

Study contacts

• Study coordinator: Zhen Professor Li, PHD,MD
• Email: zhenli@hust.edu.cn
• Phone: 02783663543

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.