Nitazoxanide with mesalamine for mild-to-moderate ulcerative colitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2 interventional trial enrolling adults with confirmed mild-to-moderate ulcerative colitis. Participants meeting eligibility will receive nitazoxanide in combination with mesalamine and be followed over the treatment period for changes in symptoms and objective markers of colonic inflammation. Exclusion criteria include severe UC, current systemic or rectal steroid use, immunosuppressive or biologic therapy, pregnancy or breastfeeding, and colorectal cancer. Clinical, endoscopic, and histologic measures will be used to judge whether the combination reduces mucosal inflammation compared with baseline.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Both male and female will be included
* Mild and moderate UC patients are already diagnosed and confirmed by endoscope and histopathology.

Exclusion Criteria:

* Breast feeding or pregnancy.
* Colorectal cancer patients.
* Patients with severe UC.
* Patients taking rectal or systemic steroids.
* Patients taking immunosuppressives or biological therapies.
* Addiction to alcohol and / or drugs.
* Known allergy to the studied medications.

Where it's running

• Alexandria University
  Alexandria, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.