Nicotinamide supplementation to enhance physical performance in older adults at risk of falls
Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls: a Pilot Randomized Clinical Trial
This study is testing if taking nicotinamide can help older adults at risk of falls improve their physical performance during a four-week home training program.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | University of Chile Academic / other |
| Locations | 1 site (Santiago) |
| Trial ID | NCT06465602 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effects of nicotinamide supplementation on physical performance in older adults who are at risk of falls. Participants aged 65 and older will undergo guided home-based physical training combined with either nicotinamide or a placebo for four weeks. The study will utilize a randomized, double-blind design to ensure unbiased results, with physical performance assessed through various tests including the Short Physical Performance Battery and handgrip strength. The trial is designed to address the challenges of implementing effective physical training in older adults by potentially enhancing their response to such interventions.
Who should consider this trial
Good fit: Ideal candidates for this study are community-dwelling adults aged 65 years or older who have an increased risk of falls.
Not a fit: Patients with known muscle diseases, severe joint pain, cognitive impairments, or significant motor sequelae from strokes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved physical performance and reduced fall risk in older adults, enhancing their quality of life.
How similar studies have performed: Previous studies have shown promising results with similar interventions aimed at improving physical performance in older adults, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 65 years or older * Living in the community * Increased risk of falls, defined as: * More than two falls in the last 12 months or * Altered balance test (unable to maintain unipedal stance \> 5 seconds) or * SPPB score less than 10 points Exclusion Criteria: * Known Muscle Disease (dystrophy, myopathy, or similar) * Motor sequelae of stroke * Joint pathology with severe pain preventing strength exercises * Cognitive impairment that renders the informed consent process impossible.
Where this trial is running
Santiago
- Hospital Clínico Universidad de Chile — Santiago, Chile (Recruiting)
Study contacts
- Principal investigator: Felipe H Salech Morales, MD-PhD — University of Chile
- Study coordinator: Felipe H Salech Morales, MD PhD
- Email: fhsalech@uchile.cl
- Phone: 229788546
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.