Nicotinamide riboside supplementation to improve metabolic flexibility during Zone 2 training
Official title: Temporal and Dose-response Effects of Nicotinamide Riboside Supplementation on Metabolic Flexibility During Zone 2 Training in Adults: a Double-blinded, Randomized, Controlled, Crossover Trial
Run by Chinese University of Hong Kong · NCT07344636 · Data updated 2026-11-12
This test will see if taking nicotinamide riboside (NR) helps healthy adults improve metabolic flexibility during Zone 2 endurance training.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong, Please Select) |
| Status | Recruiting |
| Started | January 6, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT07344636 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults over 18 with BMI under 30 who are cleared for endurance exercise and not taking vitamin B or NAD supplements are ideal candidates.
✕Probably not a fit
People with cardiovascular disease, cancer, musculoskeletal disorders, or those taking vitamin B/NAD supplements or medications that affect the outcomes are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study enrolls healthy adults (age >18, BMI <30) who will perform prescribed Zone 2 endurance training while receiving nicotinamide riboside (NR) supplementation. Metabolic outcomes related to NAD metabolism, mitochondrial function, and substrate use during exercise will be measured before and after the intervention. People currently taking vitamin B supplements or NAD precursors, or those with conditions that contraindicate exercise, are excluded. The trial is conducted on-site at The Chinese University of Hong Kong's Kwok Sports Building.
Why it matters
Potential benefit: If successful, NR supplementation could improve cellular energy metabolism and help healthy exercisers burn fat more efficiently and delay fatigue.
How similar studies have gone: Prior studies show that aerobic exercise and NR supplementation can raise NAD levels and improve mitochondrial function, but combining NR with Zone 2 training has limited direct evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over 18 years old * BMI \<30 kg/m2 Exclusion Criteria: * Present of health conditions that contraindicate participation in exercise training, such as a history of cardiovascular disease, cancer, or musculoskeletal disorders * Currently taking vitamin B supplements and/or NAD precursors * Taking medication that may affect the test results
Where it's running
-
G02, Kwok Sports Building, The Chinese University of Hong Kong
Hong Kong, Please Select, China Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Morningness vs. eveningness and how quickly healthy adults recover after submaximal exercise
This study tests whether people who prefer morning or evening are linked to how quickly healthy adults recover after a light-to-moderate workout.
-
Orally Taken TIX100 in Healthy Overweight/Obese Adults
This study will test whether daily oral TIX100 is safe and well tolerated in healthy adults who are overweight or obese.
-
YR001 Topical Ointment safety and PK in healthy Chinese adults
This study tests whether YR001 ointment is safe and tolerable and how it behaves in the body after single and repeated applications in healthy Chinese adults, compared with a placebo.
-
Does Yoga Style Affect Sleep and Heart Health in Adults with and without Insomnia
This study tests whether two styles of yoga (vinyasa and gentle yoga) done in the evening can improve sleep and heart health in adults, including those with insomnia.
-
Single-dose testing of JPH034 in healthy adults.
This trial tests single ascending doses of the experimental drug JPH034 versus placebo in healthy adults aged 18–50 to see if the drug is safe, how the body handles it, and whether food affects absorption.
-
Muscle–brain connections in older adults with and without neurological disorders
See if muscle–brain connections differ between healthy adults aged 60+ and people over 60 who have neurological disorders such as ALS, Parkinson's, Alzheimer's, or severe acquired brain injury.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.