New treatments for esophageal achalasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the long-term effectiveness of four different treatment options for esophageal achalasia, including per oral endoscopic myotomy (POEM), prolonged dilatation (PRD) with stent-fixation, balloon dilatation, and conventional laparoscopic Heller myotomy. The aim is to determine which approach provides the best symptom relief and is most effective, especially for patients who have not responded to previous treatments. The study focuses on individualized treatment plans based on patient needs and conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed diagnosis of achalsia, hypertensive lower esophageal sphincter, nutcracker esophagus, or diffuse esophageal spasm

Exclusion Criteria:

* Contraindication for EGD

Where it's running

• Department of Surgery, Medical University of Vienna
  Vienna, Austria Recruiting

Study contacts

• Study coordinator: Department of Surgery, Medical University of Vienna
• Email: sebastian.schoppmann@meduniwien.ac.at; erwin.rieder@meduniwien.ac.at
• Phone: +43 1 40400

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• POEM vs Heller myotomy with Dor fundoplication for achalasia

  This trial tests POEM against laparoscopic Heller myotomy with Dor fundoplication to see which procedure better helps adults with achalasia.

  Recruiting Minia University · Minya, Minya Governorate · NCT07814027

• Comparing Botox and surgery for stomach drainage during esophagectomy

  This study is testing whether Botox injections can help people who have had esophagus surgery manage delayed stomach emptying just as well as surgery can.

  Recruiting Phase 2/3 The Cleveland Clinic · Cleveland, Ohio · NCT06721520

• Investigating the impact of malnutrition on breathing and kidney function in achalasia patients undergoing POEM surgery

  This study is testing how malnutrition affects breathing and kidney health in patients with achalasia who are having a specific surgery called POEM.

  Recruiting Umraniye Education and Research Hospital · Istanbul · NCT06405412

• Evaluating esophageal clearance in achalasia using advanced imaging techniques

  This study is testing if a new way to measure how well the esophagus clears food can replace an older method that uses radiation for patients with achalasia who have had a specific surgery.

  Recruiting University Hospital, Bordeaux · Pessac · NCT06230536

• Comparing routine and symptom-based PPI therapy after a procedure for esophageal achalasia

  This study is testing whether giving patients with esophageal achalasia a routine 12-month prescription for heartburn medication after a specific procedure can help prevent throat inflammation better than only giving the medication when they have symptoms.

  Recruiting at 4 sites Centre Hospitalier Universitaire de Nīmes · Marseille and 3 other locations · NCT05899842

• Registry for identifying risk factors of esophageal cancer

  This study is trying to find out if certain blood and tissue markers can help identify people at risk for esophageal cancer by looking at their medical history and samples.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT00260585

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.