New treatments for esophageal achalasia
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) as Additional Endoscopic Treatment Options for Achalasia and Other Esophageal Motility Disorders
This study is testing four different treatment options for esophageal achalasia to see which one helps patients feel better, especially those who haven't had success with other treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna) |
| Trial ID | NCT02518542 on ClinicalTrials.gov |
What this trial studies
This study evaluates the long-term effectiveness of four different treatment options for esophageal achalasia, including per oral endoscopic myotomy (POEM), prolonged dilatation (PRD) with stent-fixation, balloon dilatation, and conventional laparoscopic Heller myotomy. The aim is to determine which approach provides the best symptom relief and is most effective, especially for patients who have not responded to previous treatments. The study focuses on individualized treatment plans based on patient needs and conditions.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with achalasia or related esophageal motility disorders.
Not a fit: Patients with contraindications for endoscopic procedures will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide patients with more effective treatment options for achalasia, improving their quality of life.
How similar studies have performed: Other studies have shown promising results with similar endoscopic approaches, suggesting potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed diagnosis of achalsia, hypertensive lower esophageal sphincter, nutcracker esophagus, or diffuse esophageal spasm Exclusion Criteria: * Contraindication for EGD
Where this trial is running
Vienna
- Department of Surgery, Medical University of Vienna — Vienna, Austria (Recruiting)
Study contacts
- Study coordinator: Department of Surgery, Medical University of Vienna
- Email: sebastian.schoppmann@meduniwien.ac.at; erwin.rieder@meduniwien.ac.at
- Phone: +43 1 40400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.