New test for diagnosing amoxicillin allergy
Official title: Diagnosing Drug Allergy the T is the Key
Run by University Hospital, Antwerp · NCT06409884 · Data updated 2026-11-12
This study is testing a new blood test to see if it can accurately diagnose amoxicillin allergies in people who may have them.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University Hospital, Antwerp Academic / other |
| Locations | 1 site (Edegem, Antwerp) |
| Status | Recruiting |
| Started | May 21, 2024 |
| Main results expected | September 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | May 14, 2026 |
| Trial ID | NCT06409884 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 6 years and older with a suspected history of amoxicillin allergy.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to validate a novel T-cell activation test for diagnosing amoxicillin allergy. Participants will undergo blood collection and, when applicable, allergy skin testing during multiple hospital visits. The study focuses on improving the reliability and applicability of allergy diagnostics, addressing the challenges of current testing methods. By utilizing flow-based intracellular trapping and staining techniques, the researchers hope to create a safe and effective diagnostic tool that could streamline the identification of drug allergies.
Why it matters
Potential benefit: If successful, this test could provide a more accurate and safer method for diagnosing amoxicillin allergies, reducing unnecessary challenges and misdiagnoses.
How similar studies have gone: Other studies have explored T-cell activation tests for drug allergies, but this specific approach is novel and aims to enhance diagnostic accuracy.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants are eligible if they: * Are ≥ 6 years * Are capable of informed consent, or if appropriate, participants have an acceptable individual capable of giving consent on the participant's behalf (e.g. parent or guardian of a child under 18 years of age) * Have a suspected history of amoxicillin allergy Exclusion Criteria: * Patients who are lacking capacity or do not have an acceptable individual capable to provide informed consent * Pregnant women * Breastfeeding women
Where it's running
-
Antwerp University Hospital
Edegem, Antwerp, Belgium Recruiting
Study contacts
- Principal investigator: Didier Ebo, PhD — University Hospital, Antwerp
- Study coordinator: Didier Ebo, PhD
- Email: Didier.Ebo@uza.be
- Phone: +3238215027
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.