New test for diagnosing amoxicillin allergy
Diagnosing Drug Allergy the T is the Key
This study is testing a new blood test to see if it can accurately diagnose amoxicillin allergies in people who may have them.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 6 Years and up |
| Sex | All |
| Sponsor | University Hospital, Antwerp Academic / other |
| Locations | 1 site (Edegem, Antwerp) |
| Trial ID | NCT06409884 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to validate a novel T-cell activation test for diagnosing amoxicillin allergy. Participants will undergo blood collection and, when applicable, allergy skin testing during multiple hospital visits. The study focuses on improving the reliability and applicability of allergy diagnostics, addressing the challenges of current testing methods. By utilizing flow-based intracellular trapping and staining techniques, the researchers hope to create a safe and effective diagnostic tool that could streamline the identification of drug allergies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 6 years and older with a suspected history of amoxicillin allergy.
Not a fit: Patients who are pregnant, breastfeeding, or unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this test could provide a more accurate and safer method for diagnosing amoxicillin allergies, reducing unnecessary challenges and misdiagnoses.
How similar studies have performed: Other studies have explored T-cell activation tests for drug allergies, but this specific approach is novel and aims to enhance diagnostic accuracy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants are eligible if they: * Are ≥ 6 years * Are capable of informed consent, or if appropriate, participants have an acceptable individual capable of giving consent on the participant's behalf (e.g. parent or guardian of a child under 18 years of age) * Have a suspected history of amoxicillin allergy Exclusion Criteria: * Patients who are lacking capacity or do not have an acceptable individual capable to provide informed consent * Pregnant women * Breastfeeding women
Where this trial is running
Edegem, Antwerp
- Antwerp University Hospital — Edegem, Antwerp, Belgium (Recruiting)
Study contacts
- Principal investigator: Didier Ebo, PhD — University Hospital, Antwerp
- Study coordinator: Didier Ebo, PhD
- Email: Didier.Ebo@uza.be
- Phone: +3238213526
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.