New MRI Methods for Heart Failure with Preserved Ejection Fraction (HFpEF)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will develop and test advanced MRI techniques for quantitative perfusion, fibrosis, longitudinal strain, and flow using simultaneous multi-slice and hybrid acquisitions. The aim is to see if these methods can better identify and characterize HFpEF and its microvascular remodeling. The project includes validating new arterial input function approaches with 3D stack-of-stars imaging in a single session. The study may involve adenosine, regadenoson, and other imaging modalities like PET for comprehensive assessment. It is conducted in adults at the University of Utah with NHLBI collaboration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All participants will be over the age of 18 and able to provide consent

  * Group A (volunteers, with or without cardiac disease): Volunteers will be available for at least one study visit
  * Group B (HFpEF patient volunteers): Volunteers will have a diagnosis of HFpEF and be safe to be imaged with MRI

Exclusion Criteria:

* minors
* Critically ill patients, patients on ventilators, patients with unstable angina or with hypotension, asthmatics, and other patients whose medical care or safety may be at risk from undergoing an MRI examination will be excluded.
* Patients with claustrophobia will also be excluded from the study if this cannot be controlled with standard methods (valium or benadryl).
* Patients with contraindication to MRI (metal implants, or certain types of heart valves),
* pregnant patients, , mentally disabled patients and prisoners will be excluded from this study. (All criteria apply to patients and normal volunteers).
* Gadolinium nephrotoxicity will be addressed by having patients with abnormal kidney function (GFR\<30) excluded from the study due to the (very small) risk associated with gadolinium contrast agents.
* This threshold may be modified, depending on practices determined by the Radiology Department and the IRB.
* Patients with a known allergy or contraindication to Adenosine and/or Regadenoson will be excluded from stress MRI cohorts.
* All participants that will receive a stress agent will refrain from consuming caffeine for at least 12 hours prior to each MRI
* Subjects with a known contraindication to Adenosine and/or Regadenoson will only be enrolled in scans where no stress agent will be administered

Where it's running

• university of Utah, Radiology Research
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Edward DiBella, Ph.D. — Faculty
• Study coordinator: Olivia Pratt, BS
• Email: u0447662@umail.utah.edu
• Phone: 801-585-6142

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.