New methods to measure kidney function in patients with chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate innovative techniques for assessing renal functional reserve in patients with chronic kidney diseases. It focuses on quantifying glomerular filtration rate (GFR) over time, moving beyond traditional static assessments like serum creatinine, which can underestimate kidney function loss. By examining how GFR responds to stimuli such as exercise and protein intake, the study seeks to identify early indicators of reduced renal reserve that may predict future kidney complications. The intervention involves administering dapagliflozin to assess its effects on renal function.

Why it matters

Who can join: the full rules

Inclusion:

* Patients with sickle cell nephropathy, diagnosed clinically or histologically. Sickle Cell patients will be confirmed Hb SS and eGFR (CKD-EPI) ≥ 135 ml/min/1.73m2 OR
* Previous living kidney donation
* Age ≥ 4No contraindication or known allergy to any trial medications.
* Willing and able to provide written informed consent

Exclusion:

* Aged \< 40
* Unable or unwilling to provide informed consent
* Breastfeeding or pregnant women
* Patients involved in other interventional research studies.

Where it's running

• King's College Hospital
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Kate Bramham, Doctor
• Email: kch-tr.research@nhs.net
• Phone: 0203 299 9000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.