New imaging technique to evaluate treatment response in colorectal cancer that has spread to the liver

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness of intravoxel incoherent motion diffusion weighted imaging (IVIM DWI) in detecting changes in colorectal cancer liver metastases before and after chemotherapy. The primary goal is to determine if IVIM DWI can differentiate between responders and nonresponders to treatment based on diffusion-related parameters. Additionally, the study will assess correlations between imaging changes and pathological treatment responses. Patients will undergo IVIM DWI scans during standard MRI procedures at specified intervals during their chemotherapy regimen.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with treatment-naive resectable CLM, who will start chemotherapy with oxaliplatin with fluorouracil (5-FU)/leucovorin (FOLFOX), irinotecan with 5-FU/leucovorin (FOLFIRI), or a combination, such as fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFOXIRI), with or without a biologic agent
* Patients with at least 1 colorectal liver metastasis measuring at least 1 cm
* Patients with anticipated follow-up before and after surgery at MD Anderson

Exclusion Criteria:

* Patients who have already received preoperative chemotherapy for the CLM or will undergo radiation therapy, ablative therapies, or other non-surgical therapies directed at the liver
* Patients allergic to gadolinium
* Patients with pacemakers
* Greater than 400 pounds in weight

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Priya R Bhosale — M.D. Anderson Cancer Center
• Study coordinator: Priya R Bhosale
• Email: priya.bhosale@mdanderson.org
• Phone: 713-792-0221

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.