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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

New hydration strategy to prevent kidney injury during heart procedures

Official title: ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions: a Pragmatic, Adaptive, Patient-oriented Randomized Controlled Trial

Run by Montreal Heart Institute · NCT04936607 · Data updated 2026-11-12

This study is testing a new personalized hydration method to see if it can help prevent kidney injury in people having heart procedures like angiograms.

More Contrast-Induced Acute Kidney Injury trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1158 (estimated)
SponsorMontreal Heart Institute
Academic / other
Locations1 site (Montreal, Quebec)
StatusRecruiting
StartedJune 28, 2021
Main results expectedJanuary 30, 2027
Study endsJuly 31, 2027
Registry record updatedDecember 8, 2025
Trial IDNCT04936607 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older scheduled for a coronary angiogram or PCI with a life expectancy of at least six months.

Probably not a fit

Patients experiencing cardiogenic shock, requiring emergent procedures, or with severe pre-existing conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The NEPTUNE trial evaluates a personalized intravenous hydration strategy aimed at preventing contrast-induced acute kidney injury (CI-AKI) in patients undergoing coronary angiograms and/or percutaneous coronary interventions. Participants will be randomized to receive either a tailored hydration approach based on their left ventricular end-diastolic pressure and renal function or standard hydration. The trial is triple-blind, ensuring that both participants and operators are unaware of treatment allocations. Key outcomes include the incidence of CI-AKI and major adverse renal and cardiovascular events, assessed by an independent committee.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the risk of kidney injury in patients undergoing heart procedures.

How similar studies have gone: Previous studies have explored hydration strategies for CI-AKI, but this specific adaptive approach is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥18 years;
* Planned coronary angiogram and/or PCI;
* Willingness to participate and to attend study visits;
* Expected life expectancy ≥6 months.

Exclusion Criteria:

* Cardiogenic or non-cardiogenic shock at the time of the procedure;
* Emergent procedures (e.g. STEMI);
* Iodine-based contrast media received within 2 days;
* Presence of Intra-Aortic Balloon Pump (IABP);
* Cardiac arrest within 24 hours;
* Pre-procedural AKI defined using the modified KDIGO criteria within 7 days;
* Renal replacement therapy;
* Severe aortic or mitral disease;
* LVEF \<30%.

Where it's running

  • Montreal Heart Institute
    Montreal, Quebec, Canada     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.