New biomarkers for ischemic cerebrovascular disease
Official title: A Prospective Observational Cohort Study of Predictive Biomarkers Related With Ischemic Cerebrovascular Disease
Run by Tongji Hospital · NCT06890702 · Data updated 2026-11-12
This study will test whether specific blood, cerebrospinal fluid, urine, and stool biomarkers can help diagnose and predict outcomes for people with ischemic stroke and related cerebrovascular conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 7000 (estimated) |
| Sponsor | Tongji Hospital Academic / other |
| Locations | 2 sites (Wuhan, Hubei and 1 other locations) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | December 27, 2035 |
| Study ends | January 1, 2038 |
| Registry record updated | July 28, 2026 |
| Trial ID | NCT06890702 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults diagnosed with ischemic cerebrovascular disease (including TIA, ischemic stroke, chronic cerebral hypoperfusion, or related conditions) or age- and sex-matched healthy volunteers who can provide biological samples and attend scheduled follow-ups.
✕Probably not a fit
Patients with cerebral hemorrhage, those with severe systemic disease expected to survive less than three months, or those unable to provide ongoing follow-up are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, prospective observational study that compares patients with ischemic cerebrovascular disease to age- and sex-matched healthy controls from a medical check-up center. Participants provide blood, cerebrospinal fluid, urine, and stool samples, undergo clinical imaging (CT, MRI, PET-CT) and functional assessments, and are followed at 3, 6, 12, 24, 36, and 48 months to track clinical outcomes and biomarker changes. Researchers will analyze biomarker expression differences and combine clinical and laboratory data to build a prediction model for diagnosis, progression, and treatment response. Data access is governed by an independent review panel and secure data-sharing agreements, with source data verified by certified neurologists.
Why it matters
Potential benefit: If successful, the findings could enable earlier diagnosis, more individualized treatment planning, and better prognosis prediction for people with ischemic cerebrovascular disease.
How similar studies have gone: Previous biomarker research in stroke has produced some promising but inconsistent results, so similar approaches are plausible but not yet definitively proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ischemic cerebrovascular disease has been proved by clinical symptoms and imaging examinations,including transient ischemic attack, cerebral ischemic stroke, steal syndrome, chronic cerebral hypoperfusion, ect al. * sex and age-matched healthy individuals Exclusion Criteria: * Brain CT or MRI showing cerebral hemorrhage (excluded ischemic stroke with hemorrhage transformation) * With severe systemic disease, are expected to survive \< 3 months * Patients will not able to provide continuous follow-up information
Where it's running
-
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,
Wuhan, Hubei, China Recruiting -
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,
Wuhan, Hubei, China Not yet recruiting
Study contacts
- Principal investigator: Dai-Shi Tian — Tongji Hospital
- Study coordinator: Luo-Qi Zhou
- Email: zhouluoqi@tjh.tjmu.edu.cn
- Phone: 86-27-83663337
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.